2. Gene
  3. ZCWPW1 - zinc finger CW-type and PWWP domain containing 1 Gene

ZCWPW1 - zinc finger CW-type and PWWP domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 CW 型和 PWWP 结构域 1

种属: Homo sapiens

同用名: ZCW1

基因 ID: 55063 | 基因类型: protein coding

关于 ZCWPW1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,400,872-100,428,703 (from NCBI)

This gene has 9 transcripts (splice variants), 111 orthologues and 1 paralogue. Broad expression in testis (RPKM 25.2), thyroid (RPKM 2.9) and 16 other tissues.

功能概要

启用甲基-CpG 结合活性和甲基化组蛋白结合活性。预计参与减数分裂 I； DNA 代谢过程的正调控；和精子发生。预计在减数分裂时作用于同源染色体配对的上游或内部。预测位于 XY 体内。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables methyl-CpG binding activity and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZCWPW1 基因产物(18)

mRNA Protein Name
NM_001258008.3 NP_001244937.1 zinc finger CW-type PWWP domain protein 1 isoform 2
NM_001386008.1 NP_001372937.1 zinc finger CW-type PWWP domain protein 1 isoform 14
NM_001386009.1 NP_001372938.1 zinc finger CW-type PWWP domain protein 1 isoform 10
NM_001386010.1 NP_001372939.1 zinc finger CW-type PWWP domain protein 1 isoform 3
NM_001386011.1 NP_001372940.1 zinc finger CW-type PWWP domain protein 1 isoform 12
NM_001386012.1 NP_001372941.1 zinc finger CW-type PWWP domain protein 1 isoform 7
NM_001386013.1 NP_001372942.1 zinc finger CW-type PWWP domain protein 1 isoform 6
NM_001386015.1 NP_001372944.1 zinc finger CW-type PWWP domain protein 1 isoform 11
NM_001386016.1 NP_001372945.1 zinc finger CW-type PWWP domain protein 1 isoform 4
NM_001386017.1 NP_001372946.1 zinc finger CW-type PWWP domain protein 1 isoform 5
NM_001386018.1 NP_001372947.1 zinc finger CW-type PWWP domain protein 1 isoform 6
NM_001386019.1 NP_001372948.1 zinc finger CW-type PWWP domain protein 1 isoform 10
NM_001386020.1 NP_001372949.1 zinc finger CW-type PWWP domain protein 1 isoform 2
NM_001386021.1 NP_001372950.1 zinc finger CW-type PWWP domain protein 1 isoform 13
NM_001386022.1 NP_001372951.1 zinc finger CW-type PWWP domain protein 1 isoform 8
NM_001386023.1 NP_001372952.1 zinc finger CW-type PWWP domain protein 1 isoform 9
NM_001388066.1 NP_001374995.1 zinc finger CW-type PWWP domain protein 1 isoform 15
NM_017984.6 NP_060454.3 zinc finger CW-type PWWP domain protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone reader activity IDA
IDA: 通过直接分析推断
20826339 GOA
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
32744506 GOA
enables methylated histone binding IDA
IDA: 通过直接分析推断
20826339 GOA
enables methylated histone binding IMP
IMP: 通过突变表型推断
20826339 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26871637 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZCWPW1 蛋白结构

zf-CW

zf-CW: CW-type Zinc Finger (256 - 302)

PWWP

PWWP: PWWP domain (317 - 409)

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  • 600
  • 648 a.a.
蛋白主名 其他名称

zinc finger CW-type PWWP domain protein 1

zinc finger CW-type and PWWP domain 1

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 6

Primary Ciliary Dyskinesia 6

CILD6

Ics6

Immotile Cilia Syndrome 6

Dyskinesia, Ciliary, Primary, 6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16009 ZCWPW1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZCWPW1 MGD MGI:2685899
Felis catus ZCWPW1 VGNC VGNC:67199
Rattus norvegicus ZCWPW1 RGD RGD:1305405
Canis familiaris ZCWPW1 VGNC VGNC:48575
Bos taurus ZCWPW1 VGNC VGNC:37125
Macaca mulatta ZCWPW1 VGNC VGNC:79393
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