2. Gene
  3. ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho 鸟嘌呤核苷酸交换因子 10 样

种属: Homo sapiens

同用名: GrinchGEF

基因 ID: 55160 | 基因类型: protein coding

关于 ARHGEF10L

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,513,435-17,697,875 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues, 2 paralogues and is associated with 76 phenotypes. Ubiquitous expression in kidney (RPKM 7.7), colon (RPKM 6.9) and 24 other tissues.

功能概要

该基因属于 RhoGTPases 的 RhoGEF 亚家族。该亚家族的成员被特定的鸟嘌呤核苷酸交换因子 (GEF) 激活，并参与信号转导。编码的蛋白质显示细胞溶质分布。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 6 月]

This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

ARHGEF10L 基因产物(5)

mRNA Protein Name
NM_001011722.2 NP_001011722.2 rho guanine nucleotide exchange factor 10-like protein isoform 2
NM_001319837.1 NP_001306766.1 rho guanine nucleotide exchange factor 10-like protein isoform 3
NM_001319838.1 NP_001306767.1 rho guanine nucleotide exchange factor 10-like protein isoform 4
NM_001328124.1 NP_001315053.1 rho guanine nucleotide exchange factor 10-like protein isoform 5
NM_018125.4 NP_060595.3 rho guanine nucleotide exchange factor 10-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
16112081 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SREBP signaling pathway IDA
IDA: 通过直接分析推断
16112081 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
16112081 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
16112081 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGEF10L 蛋白结构

RhoGEF

RhoGEF: RhoGEF domain (323 - 502)

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  • 1279 a.a.
蛋白主名 其他名称

rho guanine nucleotide exchange factor 10-like protein

Rho guanine nucleotide exchange factor (GEF) 10-like

关联疾病

疾病名称 别名
Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures

Postvaccinal Encephalomyelitis

Encephalomyelitis, Acute Disseminated
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00947 ARHGEF10L Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARHGEF10L VGNC VGNC:38073
Macaca mulatta ARHGEF10L VGNC VGNC:69908
Bos taurus ARHGEF10L VGNC VGNC:26105
Rattus norvegicus ARHGEF10L RGD RGD:1585585
Felis catus ARHGEF10L VGNC VGNC:59897
Mus musculus ARHGEF10L MGD MGI:1920004
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