2. Gene
  3. PRH2 - proline rich protein HaeIII subfamily 2 Gene

PRH2 - proline rich protein HaeIII subfamily 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：富脯氨酸的蛋白质 HaeIII 亚家族 2

种属: Homo sapiens

同用名: Pr; pr1/Pr2; PRP-1/PRP-2

基因 ID: 5555 | 基因类型: protein coding

关于 PRH2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,929,236-10,934,845 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 10 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 6639.8).

功能概要

该基因编码富含脯氨酸的唾液糖蛋白的异质家族成员。编码的前原蛋白在从腮腺和下颌下腺/舌下腺分泌之前经过蛋白水解处理以产生一种或多种成熟的亚型。在西方人群中，该基因座通常是双等位基因并编码富含脯氨酸的蛋白质 (PRP) 亚型、PRP-1 和 PRP-2。参考基因组编码 PRP-1 等位基因。该基因的某些等位基因与龋齿易感性有关。该基因位于 12 号染色体上一组密切相关的富含脯氨酸的唾液蛋白中。[RefSeq 提供，2015 年 10 月]

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

PRH2 基因产物(1)

mRNA Protein Name
NM_001110213.1 NP_001103683.1 salivary acidic proline-rich phosphoprotein 1月2日 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16203048 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRH2 蛋白结构

Pro-rich

Pro-rich: Proline-rich (1 - 161)

  • 0
  • 100
  • 166 a.a.
蛋白主名 其他名称

salivary acidic proline-rich phosphoprotein 1/2

acidic salivary proline-rich protein, HaeIII type, 2

关联疾病

疾病名称 别名
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Retinitis Pigmentosa 35

RP35

Retinitis Pigmentosa-35

Retinitis Pigmentosa, Type 35
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11091 PRH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11092 PRH2 Human Pre-designed siRNA Set A Pre-designed Set / 否
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z