OTUB1 - OTU deubiquitinase, ubiquitin aldehyde binding 1 Gene

中文名称：OTU 去泛素化酶，泛素醛结合 1

种属: Homo sapiens

同用名: OTB1; OTU1; HSPC263

关于 OTUB1

功能概要

该基因的产物是预测半胱氨酸蛋白酶的 OTU (卵巢肿瘤) 超家族的成员。所编码的蛋白质是一种高度特异性的泛素异肽酶，可从多聚泛素支链而非泛素化底物中切割泛素。它与另一种泛素蛋白酶和一种 E3 泛素连接酶相互作用，抑制免疫系统中的细胞因子基因转录。它被提议在特定的泛素依赖性途径中发挥作用，可能是通过为多聚泛素链生长提供编辑功能。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]