N4BP2 - NEDD4 binding protein 2 Gene

中文名称：NEDD4 结合蛋白 2

种属: Homo sapiens

同用名: B3BP

关于 N4BP2

功能概要

该基因编码的蛋白质在 N 末端区域附近包含一个多核苷酸激酶结构域 (PNK) ，在 C 末端区域附近包含一个小 MutS 相关 (Smr) 结构域。编码的蛋白质可以结合 B 细胞白血病/淋巴瘤 3 (BCL-3) 和神经前体细胞表达的、发育下调的 4 (Nedd4) 蛋白质。这种蛋白质结合并水解 ATP，可作为 5'-多核苷酸激酶发挥作用，并具有成为泛素化底物的能力。这种蛋白质可能在转录偶联的 DNA 修复或基因重组中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]