CHFR - checkpoint with forkhead and ring finger domains Gene

中文名称：带有分叉头和无名指域的检查点

种属: Homo sapiens

同用名: RNF116; RNF196

关于 CHFR

功能概要

该基因编码一种 E3 泛素蛋白连接酶，该连接酶是维持调节细胞周期进入有丝分裂的前期检查点所需的，因此可能在细胞周期进程和肿瘤发生中发挥关键作用。编码的蛋白质有一个 N 端叉头相关结构域、一个中央环指结构域和一个富含半胱氨酸的 C 端区域。已经描述了编码不同蛋白质同种型的可变剪接转录物变体。[RefSeq 提供，2014 年 3 月]

This gene encodes an E3 ubiquitin-protein Ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into Mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]