2. Gene
  3. PRKCE - protein kinase C epsilon Gene

PRKCE - protein kinase C epsilon Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C epsilon

种属: Homo sapiens

同用名: PKCE; nPKC-epsilon

基因 ID: 5581 | 基因类型: protein coding

关于 PRKCE

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:45,651,279-46,187,990 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 9 paralogues. Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues.

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。这种激酶已被证明参与许多不同的细胞功能，例如神经元通道激活、细胞凋亡、心肌缺血保护、热休克反应以及胰岛素胞吐作用。小鼠基因敲除研究表明，这种激酶对激活的巨噬细胞中脂多糖 (LPS) 介导的信号传导很重要，也可能在控制焦虑样行为中发挥作用。[RefSeq 提供，2008 年 7 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, Apoptosis, cardioprotection from ischemia, heat shock response, as well as Insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PRKCE 基因产物(23)

mRNA Protein Name
XM_011532981.4 XP_011531283.1 protein kinase C epsilon type isoform X4
XM_011532983.3 XP_011531285.1 protein kinase C epsilon type isoform X9
XM_047445096.1 XP_047301052.1 protein kinase C epsilon type isoform X2
XR_007078551.1
XM_047445098.1 XP_047301054.1 protein kinase C epsilon type isoform X2
XM_017004488.3 XP_016859977.1 protein kinase C epsilon type isoform X3
XM_047445097.1 XP_047301053.1 protein kinase C epsilon type isoform X2
XR_939695.3
XM_047445094.1 XP_047301050.1 protein kinase C epsilon type isoform X2
XM_047445095.1 XP_047301051.1 protein kinase C epsilon type isoform X2
XM_006712050.4 XP_006712113.1 protein kinase C epsilon type isoform X8
XM_047445099.1 XP_047301055.1 protein kinase C epsilon type isoform X3
XM_011532975.4 XP_011531277.1 protein kinase C epsilon type isoform X2
XM_011532980.4 XP_011531282.1 protein kinase C epsilon type isoform X4
XM_005264428.2 XP_005264485.1 protein kinase C epsilon type isoform X1
XM_017004490.3 XP_016859979.1 protein kinase C epsilon type isoform X4
XM_011532982.3 XP_011531284.1 protein kinase C epsilon type isoform X5
XM_011532971.4 XP_011531273.1 protein kinase C epsilon type isoform X2
XM_005264431.5 XP_005264488.1 protein kinase C epsilon type isoform X6
NM_005400.3 NP_005391.1 protein kinase C epsilon type
XM_011532978.3 XP_011531280.1 protein kinase C epsilon type isoform X3
XM_017004492.3 XP_016859981.1 protein kinase C epsilon type isoform X7
XM_047445100.1 XP_047301056.1 protein kinase C epsilon type isoform X10

PRKCE 蛋白结构

C2

C2: C2 domain (8 - 98)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (170 - 221)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (243 - 294)

Pkinase

Pkinase: Protein kinase domain (409 - 659)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (689 - 733)

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  • 737 a.a.
蛋白主名 其他名称

protein kinase C epsilon type

重组 PRKCE 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71208 PKCE Protein, Human (His) Q02156 (Q580-P737) ≥95%

关联疾病

疾病名称 别名
Ischemia

Acute Coronary Syndrome
Alcoholic Neuropathy

Alcoholic Polyneuropathy

Alcohol-Related Polyneuropathy

Alcohol-Induced Polyneuropathy

Alcoholic Peripheral Neuropathy
Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay

Aarskog-Ose-Pande Syndrome

Lipodystrophy, Partial, With Rieger Anomaly And Short Stature

Lipodystrophy-Rieger Anomaly-Diabetes Syndrome

Rieger Anomaly-Partial Lipodystrophy Syndrome

Partial Lipodystrophy With Rieger Anomaly And Short Stature

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay

Growth Retardation-Rieger Anomaly

Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay

SHORTS
Rift Valley Fever

Rfv - [Rift Valley Fever]
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2

SRTD2

Atd2

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 2
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11125 PRKCE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11126 Prkce Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11127 Prkce Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRKCE RGD RGD:61925
Bos taurus PRKCE VGNC VGNC:33330
Felis catus PRKCE VGNC VGNC:69060
Canis familiaris PRKCE VGNC VGNC:44980
Macaca mulatta PRKCE VGNC VGNC:76412
Mus musculus PRKCE MGD MGI:97599
Others PRKCE NCBI
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