DOK5 - docking protein 5 Gene

中文名称：对接蛋白 5

种属: Homo sapiens

同用名: IRS6; IRS-6; C20orf180

关于 DOK5

功能概要

由该基因编码的蛋白质是膜蛋白 DOK 家族的成员，膜蛋白是参与信号转导的衔接蛋白。编码的蛋白质与磷酸化受体酪氨酸激酶相互作用，介导神经突生长和 MAP 激酶通路的激活。与其他 DOK 家族蛋白不同，该蛋白不与 RASGAP 相互作用。该蛋白在系统性硬化症患者中上调，并与胰岛素样生长因子结合蛋白 5 诱导的纤维化相关。该基因的可变剪接导致多个转录本变异。[RefSeq 提供，2014 年 6 月]

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated Receptor Tyrosine Kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike Other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]