2. Gene
  3. Mad2l1 - MAD2 mitotic arrest deficient-like 1 Gene

Mad2l1 - MAD2 mitotic arrest deficient-like 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MAD2

基因 ID: 56150 | 基因类型: protein coding

关于 Mad2l1

功能概要

Predicted to enable protein C-terminus binding activity and protein homodimerization activity. Involved in negative regulation of apoptotic process and positive regulation of mitotic cell cycle spindle assembly checkpoint. Acts upstream of or within mitotic sister chromatid segregation and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including kinetochore; nucleus; and spindle pole. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Mad2l1 基因产物(2)

mRNA Protein Name
NM_001355624.1 NP_001342553.1 mitotic spindle assembly checkpoint protein MAD2A
NM_019499.5 NP_062372.2 mitotic spindle assembly checkpoint protein MAD2A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21666598 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
10892650 MGI
acts upstream of or within mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
11201745 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20870947 MGI
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: 通过突变表型推断
20870947 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
17325031 MGI
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
12355205 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17504913 MGI
located in kinetochore IDA
IDA: 通过直接分析推断
10964468 MGI
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex IPI
IPI: 通过物理相互作用推断
12006501 MGI
located in nucleus IDA
IDA: 通过直接分析推断
26919979 MGI
located in spindle pole IDA
IDA: 通过直接分析推断
10964468 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mitotic spindle assembly checkpoint protein MAD2A

MAD2 (mitotic arrest deficient, homolog)-like 1

MAD2-like protein 1

mitotic arrest deficient 2-like protein 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13649 Indibulin 99.89% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07949 MAD2L1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07950 MAD2L1BP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-123279 OM137 Inhibitor / 否
HY-RS20566 Mad2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27075 Mad2l1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mad2l1 NCBI NCBI:4085
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