PRPS2 - phosphoribosyl pyrophosphate synthetase 2 Gene

中文名称：磷酸核糖焦磷酸合成酶 2

种属: Homo sapiens

同用名: PRSII

基因 ID: 5634 | 基因类型: protein coding

关于 PRPS2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,791,412-12,824,222 (from NCBI)

This gene has 5 transcripts (splice variants), 302 orthologues and 4 paralogues. Broad expression in testis (RPKM 94.5), adrenal (RPKM 26.5) and 22 other tissues.

功能概要

该基因编码的磷酸核糖焦磷酸合成酶在嘌呤和嘧啶的合成中起着核心作用。编码的蛋白质催化 ATP 和 D-核糖 5-磷酸合成 5-磷酸核糖基 1-焦磷酸。交替剪接导致多个转录本变体。[RefSeq 提供，2010 年 3 月]

This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

PRPS2 基因产物(2)

mRNA	Protein	Name
NM_001039091.3	NP_001034180.1	ribose-phosphate pyrophosphokinase 2 isoform 1
NM_002765.5	NP_002756.1	ribose-phosphate pyrophosphokinase 2 isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRPS2 蛋白结构

Pribosyltran_N

Pribosyl_synth

0
100
200
300
318 a.a.

蛋白主名

其他名称

ribose-phosphate pyrophosphokinase 2

PPRibP synthetase

PRPS2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
种属内	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Y2H Prey Pooling	25416956
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
种属内	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Y2H Array	25416956
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Anti Tag CoIP	33961781
种属内	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Validated Y2H	25416956
种属内	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Anti Tag CoIP	33961781
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Array	31515488
种属内	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Prey Pooling	25416956
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
种属内	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	PRPS2	P11908	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	PRPS2	P11908	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	PRPS2	P11908	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	PRPS2	P11908	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	PRPS2	P11908	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	PRPS2	P11908	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	PRPS2	P11908	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
种属内	PRPS2	P11908	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRPS2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71108	PRPS2 Protein, Human (HEK293, His)	P11908 (P2-L318)	≥95%
HY-P77156	PRPS2 Protein, Human (His)	P11908-1 (M1-L318)	≥95%

关联疾病

疾病名称

别名

Arts Syndrome

ARTS	Mrxsarts
Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision	Mrxs18
Lethal Ataxia With Deafness And Optic Atrophy	Fatal X-Linked Ataxia With Deafness And Loss Of Vision
Mental Retardation, X-Linked, Syndromic, Arts Type	Mental Retardation, X-Linked, Syndromic 18
Syndromic X-Linked Mental Retardation 18	Syndromic X-Linked Mental Retardation Arts Type
Lethal Ataxia-Deafness-Optic Atrophy	X-Linked Fatal Ataxia With Deafness And Loss Of Vision
Ataxia-Deafness-Optic Atrophy, Lethal	Lethal Ataxia With Hearing Loss And Optic Atrophy
Art

Charcot-Marie-Tooth Disease, X-Linked Recessive, 5

CMTX5	Rosenberg-Chutorian Syndrome
Charcot-Marie-Tooth Disease X-Linked Recessive 5	Optic Atrophy, Polyneuropathy, And Deafness
Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5	Cmt5x
X-Linked Charcot-Marie-Tooth Disease Type 5	Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5
Optic Atrophy Polyneuropathy Deafness	Optic Atrophy With Polyneuropathy And Deafness
Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5

Deafness, X-Linked 1

DFNX1	Dfn2
Deafness, X-Linked 2, Sensorineural Congenital	X-Linked Deafness 1
X-Linked Sensorineural Congenital Deafness 2	Deafness, X-Linked, 1
Congenital Sensorineural Deafness X-Linked 2	Deafness, X-Linked, Type 1

Childhood B-Cell Acute Lymphoblastic Leukemia

B-Cell Childhood Acute Lymphoblastic Leukemia

Phosphoribosylpyrophosphate Synthetase Superactivity

PRPS1 SUPERACTIVITY	Prpp Synthetase Superactivity
Gout, Prps-Related	Prpp Synthetase Deficiency
Prpp Synthetase Overactivity	Prs Overactivity
Prs Superactivity	Mild Phosphoribosylpyrophosphate Synthetase Superactivity
Mild Prpp Synthetase Superactivity	Mild Prps1 Superactivity
Severe Phosphoribosylpyrophosphate Synthetase Superactivity	Severe Prpp Synthetase Superactivity
Severe Prps1 Superactivity	Prps-Related Gout
Superactivity, Phosphoribosylpyrophosphate Synthetase

Charcot-Marie-Tooth Disease Type X

X-Linked Nonsyndromic Deafness

X-Linked Deafness

Deafness, X-Linked

Retinitis Pigmentosa 19

RP19	Retinitis Pigmentosa-19
Retinitis Pigmentosa, Type 19

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11220	PRPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18836	Prps2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25328	Prps2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PRPS2	RGD	RGD:3415
Mus musculus	PRPS2	MGD	MGI:97776
Macaca mulatta	PRPS2	VGNC	VGNC:103849
Bos taurus	PRPS2	VGNC	VGNC:56950
Canis familiaris	PRPS2	VGNC	VGNC:45033
Others	PRPS2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRPS2 - phosphoribosyl pyrophosphate synthetase 2 Gene

关于 PRPS2

功能概要

PRPS2 基因产物(2)

PRPS2 蛋白结构

PRPS2 蛋白互作信息

重组 PRPS2 蛋白

关联疾病

直系同源

热门区域

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PRPS2 - phosphoribosyl pyrophosphate synthetase 2 Gene

关于 PRPS2

功能概要

PRPS2 基因产物(2)

PRPS2 蛋白结构

PRPS2 蛋白互作信息

重组 PRPS2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z