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  3. LGMN - legumain Gene

LGMN - legumain Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：豆豆

种属: Homo sapiens

同用名: AEP; LGMN1; PRSC1

基因 ID: 5641 | 基因类型: protein coding

关于 LGMN

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,703,809-92,748,627 (from NCBI)

This gene has 19 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 135.7), spleen (RPKM 98.7) and 23 other tissues.

功能概要

该基因编码的半胱氨酸蛋白酶对天冬酰胺键的水解具有严格的特异性。该酶可能参与细菌肽和内源性蛋白质的加工，以在溶酶体/内体系统中呈递 MHC II 类。酶活化由酸性 pH 触发，并且似乎是自催化的。蛋白质表达发生在单核细胞分化成树突状细胞后。在成熟树突细胞中脂多糖表达后，会产生一种完全成熟的活性酶。该基因的过度表达可能与大多数实体瘤类型有关。该基因在 13 号染色体上有一个假基因。已经描述了几种选择性剪接的转录物变体，但只有两种的生物学有效性得到了确定。这两个变体编码相同的异构体。[RefSeq 提供，2008 年 7 月]

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This Enzyme may be involved in the processing of Bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active Enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

LGMN 基因产物(4)

mRNA Protein Name
NM_001008530.3 NP_001008530.1 legumain isoform 1 preproprotein
NM_001363696.2 NP_001350625.1 legumain isoform 2 precursor
NM_001363699.2 NP_001350628.1 legumain isoform 3 precursor
NM_005606.7 NP_005597.3 legumain isoform 1 preproprotein

LGMN 蛋白结构

Peptidase_C13

Peptidase_C13: Peptidase C13 family (29 - 285)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
蛋白主名 其他名称

legumain

asparaginyl endopeptidase

重组 LGMN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70897 Legumain Protein, Human (HEK293, His) AAH03061.1 (I18-Y433) ≥95%

关联疾病

疾病名称 别名
Schistosomiasis

Katayama Fever

Bilharzia

Bilharziasis

Schistosomiasis Mansoni

Blood Fluke

Schistosoma Mansoni Infection

Snail Fever

Acute Schistosomiasis

Schistosomiasis Manson

Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]

Intestinal Schistosomiasis Nos

Intestinal Schistosomiasis

Egyptian Splenomegaly

Bilharziasis Of Intestine

Schistosomal Dysentery

Schistosomiasis Of Colon

Asiatic Schistosomiasis

Eastern Schistosomiasis

Schistosoma Japonicum Infection

Schistosomiasis Japonicum

Katayama Disease

Katayama Syndrome

Oriental Schistosomiasis
Aneruptive Fever

Rickettsia Helvetica Spotted Fever
Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD
Trichomoniasis

Trichomonas Infection

Trichomonas Infections

Disease Due To Trichomonadidae

Infection By Trichomonas

Trichomonadosis

Trichomonas Pruritus

Trichomonosis

Tricomoniasis
Tick Infestation

Tick Infestations
Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive

Autosomal Recessive Robinow Syndrome

Covesdem Syndrome

RRS1

Costovertebral Segmentation Defect-Mesomelia Syndrome

Rrs

Costovertebral Segmentation Defect With Mesomelia, Formerly

Covesdem Syndrome, Formerly

Costovertebral Segmentation Defect With Mesomelia

Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

Robinow, Autosomal Recessive Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07617 LGMN Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LGMN VGNC VGNC:30860
Macaca mulatta LGMN VGNC VGNC:74274
Canis familiaris LGMN VGNC VGNC:42654
Felis catus LGMN VGNC VGNC:69086
Rattus norvegicus LGMN RGD RGD:619832
Mus musculus LGMN MGD MGI:1330838
Susscrofa domestica LGMN NCBI
Others LGMN NCBI
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