LGMN - legumain Gene

中文名称：豆豆

种属: Homo sapiens

同用名: AEP; LGMN1; PRSC1

基因 ID: 5641 | 基因类型: protein coding

关于 LGMN

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,703,809-92,748,627 (from NCBI)

This gene has 19 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 135.7), spleen (RPKM 98.7) and 23 other tissues.

功能概要

该基因编码的半胱氨酸蛋白酶对天冬酰胺键的水解具有严格的特异性。该酶可能参与细菌肽和内源性蛋白质的加工，以在溶酶体/内体系统中呈递 MHC II 类。酶活化由酸性 pH 触发，并且似乎是自催化的。蛋白质表达发生在单核细胞分化成树突状细胞后。在成熟树突细胞中脂多糖表达后，会产生一种完全成熟的活性酶。该基因的过度表达可能与大多数实体瘤类型有关。该基因在 13 号染色体上有一个假基因。已经描述了几种选择性剪接的转录物变体，但只有两种的生物学有效性得到了确定。这两个变体编码相同的异构体。[RefSeq 提供，2008 年 7 月]

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of Bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

LGMN 基因产物(4)

mRNA	Protein	Name
NM_001008530.3	NP_001008530.1	legumain isoform 1 preproprotein
NM_001363696.2	NP_001350625.1	legumain isoform 2 precursor
NM_001363699.2	NP_001350628.1	legumain isoform 3 precursor
NM_005606.7	NP_005597.3	legumain isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	9821970	GOA
enables cysteine-type endopeptidase activity	IMP IMP: 通过突变表型推断	9065484	GOA
enables endopeptidase activator activity	IDA IDA: 通过直接分析推断	18374643	GOA
enables peptidase activity	IDA IDA: 通过直接分析推断	136644	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25630877	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	9821970	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: 通过直接分析推断	9872320	GOA
involved in cellular response to amyloid-beta	IDA IDA: 通过直接分析推断	25326800	GOA
involved in cellular response to calcium ion	IDA IDA: 通过直接分析推断	21237226	GOA
involved in cellular response to hepatocyte growth factor stimulus	IDA IDA: 通过直接分析推断	21237226	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	21237226	GOA
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: 通过遗传相互作用推断	18374643	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	21237226	GOA
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: 通过直接分析推断	18377911	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	21237226	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: 通过直接分析推断	18377911	GOA
involved in response to acidic pH	IDA IDA: 通过直接分析推断	18374643	GOA
involved in self proteolysis	IDA IDA: 通过直接分析推断	9821970	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18377911	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	18377911	GOA
is active in lysosomal lumen	IDA IDA: 通过直接分析推断	9872320	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	21237226	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGMN 蛋白结构

Peptidase_C13

0
100
200
300
400
433 a.a.

蛋白主名

其他名称

legumain

asparaginyl endopeptidase

LGMN 抗体

目录号	产品名	应用	反应物种
HY-P82724	Legumain Antibody (YA2469)	WB	Human, Mouse, Rat

关联疾病

疾病名称

别名

Schistosomiasis

Katayama Fever	Bilharzia
Bilharziasis	Schistosomiasis Mansoni
Blood Fluke	Schistosoma Mansoni Infection
Snail Fever	Acute Schistosomiasis
Schistosomiasis Manson	Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]
Intestinal Schistosomiasis Nos	Intestinal Schistosomiasis
Egyptian Splenomegaly	Bilharziasis Of Intestine
Schistosomal Dysentery	Schistosomiasis Of Colon
Asiatic Schistosomiasis	Eastern Schistosomiasis
Schistosoma Japonicum Infection	Schistosomiasis Japonicum
Katayama Disease	Katayama Syndrome
Oriental Schistosomiasis

Aneruptive Fever

Rickettsia Helvetica Spotted Fever

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD

Trichomoniasis

Trichomonas Infection	Trichomonas Infections
Disease Due To Trichomonadidae	Infection By Trichomonas
Trichomonadosis	Trichomonas Pruritus
Trichomonosis	Tricomoniasis

Tick Infestation

Tick Infestations

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07617	LGMN Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17268	Lgmn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23722	Lgmn Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	LGMN	VGNC	VGNC:30860
Macaca mulatta	LGMN	VGNC	VGNC:74274
Canis familiaris	LGMN	VGNC	VGNC:42654
Felis catus	LGMN	VGNC	VGNC:69086
Rattus norvegicus	LGMN	RGD	RGD:619832
Mus musculus	LGMN	MGD	MGI:1330838
Susscrofa domestica	LGMN	NCBI
Others	LGMN	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LGMN - legumain Gene

关于 LGMN

功能概要

LGMN 基因产物(4)

LGMN 蛋白结构

LGMN 抗体

关联疾病

直系同源

热门区域

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LGMN - legumain Gene

关于 LGMN

功能概要

LGMN 基因产物(4)

LGMN 蛋白结构

LGMN 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z