2. Gene
  3. Foxo1 - forkhead box O1 Gene

Foxo1 - forkhead box O1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Afxh; FKHR; Fkhr1; Foxo1a

基因 ID: 56458 | 基因类型: protein coding

关于 Foxo1

功能概要

Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to Insulin stimulus; cellular response to nitric oxide; and negative regulation of fat cell differentiation. Acts upstream of or within several processes, including Insulin Receptor signaling pathway; neuronal stem cell population maintenance; and positive regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 基因产物(1)

mRNA Protein Name
NM_019739.3 NP_062713.2 forkhead box protein O1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12488434 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
17090532 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12488434 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12219087 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: 通过遗传相互作用推断
19896444 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17090532 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
29320745 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
22514318 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17050673 MGI
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
22417654 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11353388 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
17090532 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
21196578 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
14978268 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
17681146 MGI
involved in cellular response to nitric oxide IDA
IDA: 通过直接分析推断
21196578 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
22417654 MGI
acts upstream of or within gene expression IGI
IGI: 通过遗传相互作用推断
29867121 MGI
acts upstream of or within glucose homeostasis IDA
IDA: 通过直接分析推断
21317886 MGI
acts upstream of or within insulin receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
29867121 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
12488434 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
17681146 MGI
involved in negative regulation of insulin secretion IDA
IDA: 通过直接分析推断
12219087 MGI
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: 通过遗传相互作用推断
19896444 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
29320745 MGI
acts upstream of or within positive regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
12783775 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17550780 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12783775 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12488434 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12488434 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
18497885 MGI
acts upstream of or within regulation of neural precursor cell proliferation IGI
IGI: 通过遗传相互作用推断
19896444 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17090532 MGI
involved in response to fatty acid IDA
IDA: 通过直接分析推断
32103177 MGI
acts upstream of or within response to insulin IGI
IGI: 通过遗传相互作用推断
29867121 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12488434 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
27457971 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12488434 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

forkhead box protein O1

forkhead box O1a

forkhead box protein O1A

forkhead in rhabdomyosarcoma

forkhead protein 1

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N2440 Gypenoside A Activator 99.42% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxo1 NCBI NCBI:2308
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