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  2. AZU1 - azurocidin 1 Gene

AZU1 - azurocidin 1 Gene

中文名称:天青素 1

种属: Homo sapiens

同用名: AZU; HBP; NAZC; hHBP; AZAMP; CAP37; HUMAZUR

基因 ID: 566 | 基因类型: protein coding

关于 AZU1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:827,837-832,018 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 238 orthologues and 6 paralogues. Restricted expression toward bone marrow (RPKM 1256.4).

功能概要

Azurophil granules 是中性粒细胞的特殊溶酶体,含有至少 10 种与杀死微生物有关的蛋白质。该基因编码一种前原蛋白,该蛋白经过蛋白水解处理后生成成熟的嗜苯胺青颗粒抗生素蛋白,具有单核细胞趋化性和抗菌活性。它也是一种重要的多功能炎症介质。这种编码的蛋白质是丝氨酸蛋白酶基因家族的成员,但它不是丝氨酸蛋白酶,因为活性位点丝氨酸和组氨酸残基被替换。编码这种蛋白质、中性粒细胞弹性蛋白酶 2 和蛋白酶 3 的基因位于染色体 19pter 的簇中。所有 3 个基因协调表达,它们的蛋白质产物在中性粒细胞分化过程中一起包装成天青粒细胞颗粒。[RefSeq 提供,2015 年 11 月]

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of Microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule Antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil Elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

AZU1 基因产物(1)

mRNA Protein Name
NM_001700.5 NP_001691.1 azurocidin preproprotein

AZU1 蛋白结构

Trypsin

Trypsin: Trypsin (27 - 239)

  • 0
  • 100
  • 200
  • 251 a.a.
蛋白主名 其他名称

azurocidin

cationic antimicrobial protein 37

重组 AZU1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7624 Azurocidin Protein, Human (HEK293, His) P20160 (I27-P250) ≥95%

关联疾病

疾病名称 别名
Erysipelas
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome

Arthropathy-Camptodactyly Syndrome

Pericarditis-Arthropathy-Camptodactyly Syndrome

Xyy Syndrome

Pac Syndrome

Cacp Syndrome

CACP

Fibrosing Serositis, Familial

Camptodactyly-Arthropathy-Pericarditis Syndrome

Cap Syndrome

47, Xyy Syndrome

47,Xyy Syndrome

Double Y Syndrome

Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

Hypertrophic Synovitis, Congenital Familial

Congenital Familial Hypertrophic Synovitis

Xyy Karyotype

Y Disomy

Yy Syndrome

Familial Fibrosing Serositis

Disomy Y

Double Y

Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

Arthropathy Camptodactyly Syndrome

Camptodactyly Arthropathy Pericarditis Syndrome

Pericarditis Arthropathy Camptodactyly Syndrome

Jacob'S Syndrome

47,Xyy

Cdags Syndrome

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage
Cornea Cancer

Malignant Neoplasm Of Cornea

Neoplasm Of Cornea

Corneal Tumor

Malignant Corneal Tumor

Malignant Tumor Of Cornea

Primary Malignant Neoplasm Of Cornea

Congenital Disorder Of Glycosylation, Type Ig

CDG1G

Alg12-Congenital Disorder Of Glycosylation

Cdg Ig

Congenital Disorder Of Glycosylation Type 1g

Congenital Disorder Of Glycosylation Type Ig

Cdgig

Congenital Disorder Of Glycosylation Ig

Congenital Disorder Of Glycosylation 1g

Cdg-Ig

Alg12-Cdg

Cdg Syndrome Type Ig

Carbohydrate Deficient Glycoprotein Syndrome Type Ig

Mannosyltransferase 8 Deficiency

Glycosylation, Congenital Disorder Of, Type Ig

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease

Sinusoidal Obstruction Syndrome

Hepatic Venoocclusive Disease

Venoocclusive Disease

Hepatic Vein Thrombosis

Budd-Chiari Syndrome

Hepatic Vein Occlusion

Veno-Occlusive Disease Of The Liver

Viral Meningitis

Meningitis Viral

Meningitis, Viral

Viral Meningitis Nec

Pericarditis
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Necrotizing Fasciitis

Fasciitis, Necrotizing

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma