2. Gene
  3. PCLO - Pclo piccolo (presynaptic cytomatrix protein) Gene

PCLO - Pclo piccolo (presynaptic cytomatrix protein) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: aczonin

基因 ID: 56768 | 基因类型: protein coding

关于 PCLO

功能概要

Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in several processes, including positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; and regulation of endosome size. Located in several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

PCLO 基因产物(2)

mRNA Protein Name
NM_001110797.2 NP_001104267.2 protein piccolo isoform 2
NM_020098.2 NP_064483.2 protein piccolo isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
11285225 RGD
enables calcium-dependent phospholipid binding IDA
IDA: 通过直接分析推断
11285225 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12473661 RGD
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
25652077 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in modulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
31074746 RGD
involved in positive regulation of synaptic vesicle recycling IMP
IMP: 通过突变表型推断
31074746 RGD
involved in presynaptic active zone assembly IDA
IDA: 通过直接分析推断
22875941 RGD
involved in regulation of endosome size IMP
IMP: 通过突变表型推断
31074746 RGD
involved in regulation of ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
23403927 RGD
involved in synapse organization IDA
IDA: 通过直接分析推断
23403927 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi-associated vesicle IDA
IDA: 通过直接分析推断
22875941 RGD
located in axon IDA
IDA: 通过直接分析推断
11182086 RGD
located in cone cell pedicle IDA
IDA: 通过直接分析推断
11596050 RGD
located in cytoskeleton of presynaptic active zone IDA
IDA: 通过直接分析推断
11596050 RGD
located in dendrite IDA
IDA: 通过直接分析推断
11182086 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21712437 RGD
located in growth cone IDA
IDA: 通过直接分析推断
11182086 RGD
located in inhibitory synapse IDA
IDA: 通过直接分析推断
11596050 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
17156365 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11182086 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
21712437 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17156365 RGD
located in presynaptic active zone IDA
IDA: 通过直接分析推断
11182086 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: 通过直接分析推断
21712437 RGD
located in ribbon synapse IDA
IDA: 通过直接分析推断
21712437 RGD
located in rod spherule IDA
IDA: 通过直接分析推断
11596050 RGD
located in synapse IDA
IDA: 通过直接分析推断
10707984 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
11182086 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
16373352 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein piccolo

multidomain presynaptic cytomatrix protein Piccolo

presynaptic cytomatrix protein

protein piccolo-like

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10155 PCLO Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22272 Pclo Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS28795 Pclo Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens PCLO NCBI NCBI:27445
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