2. Gene
  3. Pth1r - parathyroid hormone 1 receptor Gene

Pth1r - parathyroid hormone 1 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Pthr; Pthr1; PTHrel

基因 ID: 56813 | 基因类型: protein coding

关于 Pth1r

功能概要

Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Pth1r 基因产物(1)

mRNA Protein Name
NM_020073.2 NP_064458.1 parathyroid hormone/parathyroid hormone-related peptide receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables parathyroid hormone receptor activity IDA
IDA: 通过直接分析推断
1313566 RGD
enables peptide hormone binding IDA
IDA: 通过直接分析推断
9054374 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
IMP: 通过突变表型推断
8662729 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19608645 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19608645 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9054374 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
1313566 RGD
involved in positive regulation of inositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
19608645 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
19608645 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12647298 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
12647298 RGD
part of receptor complex IDA
IDA: 通过直接分析推断
19608645 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

parathyroid hormone/parathyroid hormone-related peptide receptor

PTH/PTHr receptor

PTH/PTHrP type I receptor

PTH1 receptor

parathyroid hormone receptor 1

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.32% 否
HY-120398 CH5447240 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pth1r NCBI NCBI:5745
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