PMEPA1 - prostate transmembrane protein, androgen induced 1 Gene

中文名称：前列腺跨膜蛋白，雄激素诱导 1

种属: Homo sapiens

同用名: STAG1; TMEPAI

基因 ID: 56937 | 基因类型: protein coding

关于 PMEPA1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,648,396-57,711,472 (from NCBI)

This gene has 8 transcripts (splice variants), 94 orthologues and 1 paralogue. Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues.

功能概要

该基因编码包含 Smad 相互作用基序 (SIM) 的跨膜蛋白。该基因的表达由雄激素和转化生长因子β诱导，编码的蛋白质通过与 Smad 蛋白相互作用抑制雄激素受体和转化生长因子β信号通路。该基因的过度表达可能在多种类型的癌症中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the Androgen Receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

PMEPA1 基因产物(5)

mRNA	Protein	Name
NM_001255976.2	NP_001242905.1	protein TMEPAI isoform d
NM_020182.5	NP_064567.2	protein TMEPAI isoform a
NM_199169.3	NP_954638.1	protein TMEPAI isoform b
NM_199170.3	NP_954639.1	protein TMEPAI isoform c precursor
NM_199171.3	NP_954640.1	protein TMEPAI isoform c precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables R-SMAD binding	IPI IPI: 通过物理相互作用推断	20129061	GOA
enables WW domain binding	IPI IPI: 通过物理相互作用推断	12907594	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24627487	GOA
enables protein sequestering activity	IDA IDA: 通过直接分析推断	20129061	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of SMAD protein signal transduction	IDA IDA: 通过直接分析推断	24627487	GOA
involved in negative regulation of SMAD protein signal transduction	IMP IMP: 通过突变表型推断	20129061	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	24627487	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	20129061	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	20129061	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	24627487	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	20129061	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

protein TMEPAI

solid tumor-associated 1 protein

关联疾病

疾病名称

别名

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10761	PMEPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PMEPA1	RGD	RGD:1308255
Mus musculus	PMEPA1	MGD	MGI:1929600
Canis familiaris	PMEPA1	VGNC	VGNC:44731
Macaca mulatta	PMEPA1	VGNC	VGNC:76023
Bos taurus	PMEPA1	VGNC	VGNC:33070
Felis catus	PMEPA1	VGNC	VGNC:64255

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PMEPA1 - prostate transmembrane protein, androgen induced 1 Gene

关于 PMEPA1

功能概要

PMEPA1 基因产物(5)

关联疾病

直系同源

热门区域

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PMEPA1 - prostate transmembrane protein, androgen induced 1 Gene

关于 PMEPA1

功能概要

PMEPA1 基因产物(5)

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z