2. Gene
  3. Slc12a5 - solute carrier family 12, member 5 Gene

Slc12a5 - solute carrier family 12, member 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KCC2; mKIAA1176

基因 ID: 57138 | 基因类型: protein coding

关于 Slc12a5

功能概要

Enables potassium:chloride symporter activity. Acts upstream of or within several processes, including chloride transport; learning; and thermosensory behavior. Located in dendritic shaft; neuronal cell body; and plasma membrane. Is expressed in several structures, including central nervous system and retina. Used to study epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Orthologous to human SLC12A5 (solute carrier family 12 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a5 基因产物(3)

mRNA Protein Name
NM_001355480.1 NP_001342409.1 solute carrier family 12 member 5 isoform 1
NM_001355481.1 NP_001342410.1 solute carrier family 12 member 5 isoform 2
NM_020333.2 NP_065066.2 solute carrier family 12 member 5 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables potassium:chloride symporter activity IMP
IMP: 通过突变表型推断
11395011 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chemical synaptic transmission IMP
IMP: 通过突变表型推断
11395011 MGI
acts upstream of or within chloride transport IMP
IMP: 通过突变表型推断
11395011 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
15813942 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
15813942 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
15813942 MGI
acts upstream of or within thermosensory behavior IMP
IMP: 通过突变表型推断
15813942 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
25716834 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
25716834 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11395011 MGI
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
11395011 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

solute carrier family 12 member 5

K-Cl cotransporter 2

electroneutral potassium-chloride cotransporter 2

mKCC2

neuronal K-Cl cotransporter

Slc12a5 抗体

目录号 产品名 应用 反应物种
HY-P87092 Slc12a5/KCC2 Antibody (YA6785) IHC-F, WB Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160082 KCC2 Modulator-2 Modulator / 否
HY-RS13000 SLC12A5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc12a5 NCBI NCBI:57468
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