2. Gene
  3. ZMIZ1 - zinc finger MIZ-type containing 1 Gene

ZMIZ1 - zinc finger MIZ-type containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 MIZ 型 1

种属: Homo sapiens

同用名: MIZ; RAI17; ZIMP10; NEDDFSA; TRAFIP10

基因 ID: 57178 | 基因类型: protein coding

关于 ZMIZ1

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:79,068,966-79,316,519 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 21.7), spleen (RPKM 21.6) and 25 other tissues.

功能概要

该基因编码 PIAS (激活 STAT 的蛋白质抑制剂) 蛋白质家族的成员。编码的蛋白质调节各种转录因子的活性，包括雄激素受体、Smad3/4 和 p53。编码的蛋白质也可能在 sumoylation 中发挥作用。 10 号染色体上的该基因座与 9 号染色体上的蛋白酪氨酸激酶 ABL1 基因座之间的易位与急性淋巴细胞白血病有关。[RefSeq 提供，2010 年 3 月]

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the Androgen Receptor, SMAD3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

ZMIZ1 基因产物(1)

mRNA Protein Name
NM_020338.4 NP_065071.1 zinc finger MIZ domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IPI
IPI: 通过物理相互作用推断
16777850 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
14609956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SMAD protein signal transduction IDA
IDA: 通过直接分析推断
16777850 GOA
involved in androgen receptor signaling pathway IDA
IDA: 通过直接分析推断
14609956 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14609956 GOA
involved in pyramidal neuron migration to cerebral cortex IMP
IMP: 通过突变表型推断
30639322 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
16777850 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14609956 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
14609956 GOA
located in nucleus IDA
IDA: 通过直接分析推断
30639322 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZMIZ1 蛋白结构

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (738 - 786)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1067 a.a.
蛋白主名 其他名称

zinc finger MIZ domain-containing protein 1

retinoic acid induced 17

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Dysmorphic Facies And Distal Skeletal Anomalies

NEDDFSA
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Inflammatory Bowel Disease 24

IBD24
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16087 ZMIZ1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZMIZ1 MGD MGI:3040693
Bos taurus ZMIZ1 VGNC VGNC:37195
Macaca mulatta ZMIZ1 VGNC VGNC:79036
Rattus norvegicus ZMIZ1 RGD RGD:1311620
Canis familiaris ZMIZ1 VGNC VGNC:48643
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z