Park7 - Parkinson disease (autosomal recessive, early onset) 7 Gene

种属: Mus musculus

同用名: Dj1; DJ-1

基因 ID: 57320 | 基因类型: protein coding

关于 Park7

功能概要

Enables oxygen sensor activity and peroxiredoxin activity. Involved in several processes, including detoxification of inorganic compound; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of protein metabolic process. Acts upstream of or within several processes, including dopamine uptake involved in synaptic transmission; membrane hyperpolarization; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Located in several cellular components, including cell body; endoplasmic reticulum; and mitochondrion. Is expressed in central nervous system and retina. Used to study Parkinson's disease 7. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Apr 2022]

Park7 基因产物(1)

mRNA	Protein	Name
NM_020569.3	NP_065594.2	Parkinson disease protein 7 homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables oxygen sensor activity	IMP IMP: 通过突变表型推断	17766438	MGI
enables peroxiredoxin activity	IMP IMP: 通过突变表型推断	17766438	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	14752510	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within adult locomotory behavior	IMP IMP: 通过突变表型推断	15721235	MGI
involved in cellular response to glyoxal	IMP IMP: 通过突变表型推断	22523093	MGI
involved in cellular response to oxidative stress	IMP IMP: 通过突变表型推断	21068725	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: 通过突变表型推断	16624565	MGI
involved in detection of oxidative stress	IMP IMP: 通过突变表型推断	17766438	MGI
involved in detoxification of copper ion	IMP IMP: 通过突变表型推断	23792957	MGI
involved in detoxification of mercury ion	IMP IMP: 通过突变表型推断	23792957	MGI
acts upstream of or within dopamine uptake involved in synaptic transmission	IMP IMP: 通过突变表型推断	15721235	MGI
involved in glucose homeostasis	IMP IMP: 通过突变表型推断	22611253	MGI
involved in glycolate biosynthetic process	IDA IDA: 通过直接分析推断	22523093	MGI
involved in glyoxal metabolic process	IDA IDA: 通过直接分析推断	22523093	MGI
acts upstream of or within hydrogen peroxide metabolic process	IMP IMP: 通过突变表型推断	17766438	MGI
involved in insulin secretion	IMP IMP: 通过突变表型推断	22611253	MGI
acts upstream of or within membrane depolarization	IMP IMP: 通过突变表型推断	16624565	MGI
acts upstream of or within membrane hyperpolarization	IMP IMP: 通过突变表型推断	16624565	MGI
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	20186336	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	14652021	MGI
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	14652021	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IMP IMP: 通过突变表型推断	24947010	MGI
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	22523093	MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	24899725	MGI
involved in negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	24899725	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	24899725	MGI
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: 通过突变表型推断	22611253	MGI
involved in positive regulation of NAD(P)H oxidase activity	IMP IMP: 通过突变表型推断	26021615	MGI
involved in positive regulation of acute inflammatory response to antigenic stimulus	IMP IMP: 通过突变表型推断	26021615	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	22492997	MGI
involved in positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP IMP: 通过突变表型推断	19822128	MGI
involved in positive regulation of oxidative phosphorylation uncoupler activity	IMP IMP: 通过突变表型推断	21068725	MGI
acts upstream of or within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	22555455	MGI
acts upstream of or within positive regulation of reactive oxygen species biosynthetic process	IDA IDA: 通过直接分析推断	22555455	MGI
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17015834	MGI
involved in protein stabilization	IMP IMP: 通过突变表型推断	17015834	MGI
involved in regulation of inflammatory response	IMP IMP: 通过突变表型推断	19276172	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: 通过直接分析推断	29386384	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: 通过突变表型推断	29386384	MGI
acts upstream of or within response to hydrogen peroxide	IDA IDA: 通过直接分析推断	15784737	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: 通过突变表型推断	15784737	MGI
involved in response to oxidative stress	IMP IMP: 通过突变表型推断	15784737	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: 通过突变表型推断	15799973	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell body	IDA IDA: 通过直接分析推断	24947010	MGI
located in cytosol	IDA IDA: 通过直接分析推断	15944198	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	22555455	MGI
located in mitochondrial intermembrane space	IDA IDA: 通过直接分析推断	15944198	MGI
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	15944198	MGI
located in mitochondrion	IDA IDA: 通过直接分析推断	15944198	MGI
located in neuron projection	IDA IDA: 通过直接分析推断	24947010	MGI
located in nucleus	IDA IDA: 通过直接分析推断	22555455	MGI
is active in synaptic vesicle	IDA IDA: 通过直接分析推断	29386384	MGI
is active in synaptic vesicle	IMP IMP: 通过突变表型推断	29386384	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

Parkinson disease protein 7 homolog

RNA-binding protein regulatory subunit	maillard deglycase
parkinson disease protein 7 homolog	parkinsonism-associated deglycase
protein DJ-1	protein deglycase DJ-1
protein/nucleic acid deglycase DJ-1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-163562	JYQ-164	Inhibitor	99.43%	否
HY-163563	JYQ-173		99.78%	否
HY-RS10043	PARK7 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-163564	JYQ-194		98.05%	否
HY-RS17611	Park7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24071	Park7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Park7	NCBI	NCBI:11315

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Park7 - Parkinson disease (autosomal recessive, early onset) 7 Gene

关于 Park7

功能概要

Park7 基因产物(1)

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Park7 - Parkinson disease (autosomal recessive, early onset) 7 Gene

关于 Park7

功能概要

Park7 基因产物(1)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z