1. Gene
  2. PTGIR - prostaglandin I2 receptor Gene

PTGIR - prostaglandin I2 receptor Gene

中文名称:前列腺素 I2 受体

种属: Homo sapiens

同用名: IP; PRIPR

基因 ID: 5739 | 基因类型: protein coding

关于 PTGIR

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,610,687-46,625,089 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 50.8), placenta (RPKM 17.2) and 24 other tissues.

功能概要

由该基因编码的蛋白质是 G 蛋白偶联受体家族 1 的成员,已被证明是前列环素的受体。前列环素是大血管内皮中环加氧酶的主要产物,通过与该受体结合可引起有效的血管舒张和血小板聚集抑制。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

PTGIR 基因产物(6)

mRNA Protein Name
XR_430206.4
XR_243945.4
XM_005259093.4 XP_005259150.1 prostacyclin receptor isoform X1
XR_935844.3
NM_000960.4 NP_000951.1 prostacyclin receptor
XM_005259095.5 XP_005259152.1 prostacyclin receptor isoform X2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
20622039 GOA
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
20622039 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20622039 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20622039 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTGIR 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (30 - 291)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

prostacyclin receptor

PGI receptor

PGI2 receptor

prostaglandin I2 (prostacyclin) receptor (IP)

prostanoid IP receptor

关联疾病

疾病名称 别名
Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease

Obstructive Disease Of The Pulmonary Veins

Pvod

Isolated Pulmonary Venous Sclerosis

Venous Form Of Primary Pulmonary Hypertension

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Pulmonary Valve Insufficiency

Pulmonary Regurgitation

Pulmonary Incompetence

Pulmonary Incompetence, Non-Rheumatic

Pulmonary Insufficiency Following Trauma And Surgery

Pulmonary Regurg.

Pulmonic Insufficiency

Pulmonic Valve Regurgitation

Pulmonary Valve Incompetence

Pulmonary Valve Incompetency

Pulmonary Valvular Insufficiency

Pulmonary Valvular Regurgitation

Pulmonary Valvular Incompetency

Pulmonary Valve Incompetence Nos

Annular Incompetency Pulmonary Valve

Incompetent Pulmonary Valve

Graham Steell Murmur

Pulmonary Valvular Incompetence

Fibromuscular Dysplasia
Erythroleukemia
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTGIR VGNC VGNC:49149
Rattus norvegicus PTGIR RGD RGD:1310890
Mus musculus PTGIR MGD MGI:99535
Felis catus PTGIR VGNC VGNC:69145
Canis familiaris PTGIR VGNC VGNC:49027
Macaca mulatta PTGIR VGNC VGNC:76586