UGT2A2 - UDP glucuronosyltransferase family 2 member A2 Gene

中文名称：UDP 葡萄糖醛酸转移酶家族 2 成员 A2

种属: Homo sapiens

同用名: UDPGT 2A2

基因 ID: 574537 | 基因类型: protein coding

关于 UGT2A2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,588,417-69,639,642 (from NCBI)

This gene has 2 transcripts (splice variants), 1154 orthologues and 21 paralogues. Biased expression in kidney (RPKM 3.0), liver (RPKM 2.9) and 1 other tissue.

功能概要

该基因编码的蛋白质属于 UDP-糖基转移酶家族。这个蛋白质家族的成员在结合和随后消除潜在有毒的外源性化合物和内源性化合物中发挥作用。编码的酶在嗅觉神经上皮细胞中表达，嗅觉神经上皮细胞排列在后鼻腔内，并暴露于各种气味剂和空气传播的有毒化合物。因此，有人建议这种蛋白质参与从感觉上皮细胞中清除亲脂性气味分子。该基因与 UDP 葡萄糖醛酸转移酶 2A1 家族成员共享外显子结构，后者编码 N 末端不同的亚型。该基因的多态性可能与一些人在 SARS-CoV-2 感染期间报告的味觉和嗅觉丧失有关。[RefSeq 提供，2022 年 1 月]

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 Infection. [provided by RefSeq, Jan 2022]

UGT2A2 基因产物(2)

mRNA	Protein	Name
NM_001105677.2	NP_001099147.2	UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i1
NM_001301233.1	NP_001288162.1	UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glucuronosyltransferase activity	IDA IDA: 通过直接分析推断	19858781	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in bile acid metabolic process	IDA IDA: 通过直接分析推断	23756265	GOA
involved in cellular glucuronidation	IDA IDA: 通过直接分析推断	19858781	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UGT2A2 蛋白结构

UDPGT

0
100
200
300
400
500
536 a.a.

蛋白主名

其他名称

UDP-glucuronosyltransferase 2A2

UDP glucuronosyltransferase 2 family, polypeptide A2

关联疾病

疾病名称

别名

Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome	Crigler-Najjar Syndrome Type 1
Bilirubin Udp Glucuronyl Transferase Deficiency	Crigler Najjar Syndrome
Crigler Najjar Syndrome, Type 1	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency
Bilirubin-Ugt Deficiency	Hyperbilirubinemia, Crigler-Najjar Type I
Hblrcn1	Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Hereditary Unconjugated Hyperbilirubinemia	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1
Bilirubin-Ugt Deficiency Type 1	Crigler-Najjar Syndrome 1
CN1	Cn-I
Crigler-Najjar Syndrome Type I	Hereditary Unconjugated Hyperbilirubinaemia
Ugt Deficiency	Bilirubin Glucuronosyltransferase Deficiency
Crigler-Najjar Disease Or Syndrome	Deficiency Of Glucuronosyltransferase
Glucuronyl Transferase Deficiency	Glucuronyltransferase Deficiency
Udp Glucuronyl Transferase Deficiency	Cns - [Crigler-Najjar Syndrome]
Congenital Familial Nonhemolytic Jaundice

Kernicterus

Bilirubin Encephalopathy	Hyperbilirubinemic Encephalopathy
Kernicterus Spectrum Disorder

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15435	UGT2A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UGT2A2	MGD	MGI:3576095

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UGT2A2 - UDP glucuronosyltransferase family 2 member A2 Gene

关于 UGT2A2

功能概要

UGT2A2 基因产物(2)

UGT2A2 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

UGT2A2 - UDP glucuronosyltransferase family 2 member A2 Gene

关于 UGT2A2

功能概要

UGT2A2 基因产物(2)

UGT2A2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z