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  2. SYT13 - synaptotagmin 13 Gene

SYT13 - synaptotagmin 13 Gene

中文名称:突触结合蛋白 13

种属: Homo sapiens

基因 ID: 57586 | 基因类型: protein coding

关于 SYT13

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,240,302-45,286,341 (from NCBI)

This gene has 3 transcripts (splice variants), 163 orthologues and 31 paralogues. Biased expression in brain (RPKM 27.1), gall bladder (RPKM 14.8) and 7 other tissues.

功能概要

该基因编码大突触结合蛋白家族的成员。家族成员有一个胞外 N 末端跨膜结构域和一个胞质 C 末端,带有两个串联 C2 结构域 (C2A 和 C2B) 。突触结合蛋白家族成员可以相互形成同聚和异聚复合物。它们还具有不同的生化特性和发育概况,以及组织分布模式。突触结合蛋白在多细胞生物中充当膜贩运者。已针对该基因描述了编码不同蛋白质亚型的两种可变剪接转录物变体。[RefSeq 提供,2011 年 10 月]

This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each Other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

SYT13 基因产物(2)

mRNA Protein Name
NM_001247987.2 NP_001234916.1 synaptotagmin-13 isoform 2
NM_020826.3 NP_065877.1 synaptotagmin-13 isoform 1

SYT13 蛋白结构

C2

C2: C2 domain (187 - 258)

C2

C2: C2 domain (305 - 393)

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  • 426 a.a.
蛋白主名 其他名称

synaptotagmin-13

synaptotagmin XIII

直系同源

种属 基因名 来源 基因 ID
Felis catus SYT13 VGNC VGNC:65895
Mus musculus SYT13 MGD MGI:1933945
Rattus norvegicus SYT13 RGD RGD:621877
Canis familiaris SYT13 VGNC VGNC:47044
Bos taurus SYT13 VGNC VGNC:35539
Macaca mulatta SYT13 VGNC VGNC:78121