RIC1 - RIC1 homolog, RAB6A GEF complex partner 1 Gene

中文名称：RIC1 同源物，RAB6A GEF 复杂伙伴 1

种属: Homo sapiens

同用名: CATIFA; CIP150; KIAA1432; bA207C16.1

基因 ID: 57589 | 基因类型: protein coding

关于 RIC1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,629,107-5,778,633 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 6.0), testis (RPKM 5.0) and 25 other tissues.

功能概要

启用胍基核苷酸交换因子活性和小 GTP 酶结合活性。参与多个过程，包括 GTPase 活性的正向调节；细胞外基质成分分泌的调节；和逆行运输，内体到高尔基体。位于胞质溶胶和膜中。 Ric1-Rgp1 胍基-核苷酸交换因子复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

RIC1 基因产物(3)

mRNA	Protein	Name
NM_001135920.4	NP_001129392.2	guanine nucleotide exchange factor subunit RIC1 isoform b
NM_001206557.2	NP_001193486.1	guanine nucleotide exchange factor subunit RIC1 isoform c
NM_020829.4	NP_065880.2	guanine nucleotide exchange factor subunit RIC1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	23091056	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23091056	GOA
enables small GTPase binding	IDA IDA: 通过直接分析推断	23091056	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cranial skeletal system development	IMP IMP: 通过突变表型推断	31932796	GOA
involved in negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	23091056	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	23091056	GOA
involved in regulation of extracellular matrix constituent secretion	IMP IMP: 通过突变表型推断	31932796	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: 通过突变表型推断	23091056	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	IDA IDA: 通过直接分析推断	23091056	GOA
located in cytosol	IDA IDA: 通过直接分析推断	23091056	GOA
located in membrane	IDA IDA: 通过直接分析推断	23091056	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	23091056	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RIC1 蛋白结构

RIC1

0
300
600
900
1200
1423 a.a.

蛋白主名

其他名称

guanine nucleotide exchange factor subunit RIC1

RAB6A GEF complex partner 1

关联疾病

疾病名称

别名

Catifa Syndrome

CATIFA	Cleft Lip, Cataract, Tooth Abnormality, Impaired Intellectual Development, Facial Dysmorphism, And Attention-Deficit Hyperactivity Disorder
Cleft Lip, Cataract, Tooth Abnormality, Intellectual Disability, Facial Dysmorphism, Attention-Deficit Hyperactivity Disorder

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Hodgkin'S Lymphoma, Nodular Sclerosis

Classical Hodgkin Lymphoma, Nodular Sclerosis	Classic Hodgkin Lymphoma, Nodular Sclerosis Type
Nodular Sclerosis Hodgkin Lymphoma	Hodgkin'S Disease, Nodular Sclerosis
Hodgkin Disease, Nodular Sclerosis	Hodgkin Lymphoma, Nodular Sclerosis
Hodgkin Nodular Sclerosis

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11965	RIC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RIC1	VGNC	VGNC:33959
Felis catus	RIC1	VGNC	VGNC:64623
Canis familiaris	RIC1	VGNC	VGNC:45570
Rattus norvegicus	RIC1	RGD	RGD:1310016
Mus musculus	RIC1	MGD	MGI:1924893

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RIC1 - RIC1 homolog, RAB6A GEF complex partner 1 Gene

关于 RIC1

功能概要

RIC1 基因产物(3)

RIC1 蛋白结构

关联疾病

直系同源

热门区域

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RIC1 - RIC1 homolog, RAB6A GEF complex partner 1 Gene

关于 RIC1

功能概要

RIC1 基因产物(3)

RIC1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z