2. Gene
  3. ZFAT - zinc finger and AT-hook domain containing Gene

ZFAT - zinc finger and AT-hook domain containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指和 AT-hook 结构域

种属: Homo sapiens

同用名: AITD3; ZFAT1; ZNF406

基因 ID: 57623 | 基因类型: protein coding

关于 ZFAT

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:134,477,788-134,832,339 (from NCBI)

This gene has 17 transcripts (splice variants), 203 orthologues, 38 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 4.4), kidney (RPKM 1.1) and 17 other tissues.

功能概要

该基因编码的蛋白质可能与 DNA 结合，并作为参与细胞凋亡和细胞存活的转录调节因子发挥作用。该基因位于染色体 8q24 上自身免疫性甲状腺疾病 (AITD) 的易感位点。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 11 月]

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in Apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

ZFAT 基因产物(6)

mRNA Protein Name
NM_001029939.4 NP_001025110.2 zinc finger protein ZFAT isoform 2
NM_001167583.3 NP_001161055.1 zinc finger protein ZFAT isoform 2
NM_001174157.2 NP_001167628.1 zinc finger protein ZFAT isoform 3
NM_001174158.2 NP_001167629.1 zinc finger protein ZFAT isoform 4
NM_001289394.2 NP_001276323.1 zinc finger protein ZFAT isoform 2
NM_020863.4 NP_065914.2 zinc finger protein ZFAT isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
36162510 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFAT 蛋白结构

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (117 - 135)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (285 - 307)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (313 - 335)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (404 - 426)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (432 - 454)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (458 - 481)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (743 - 764)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (770 - 793)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (830 - 853)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (895 - 918)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (939 - 959)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (966 - 988)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (994 - 1018)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1042 - 1064)

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  • 1243 a.a.
蛋白主名 其他名称

zinc finger protein ZFAT

zinc finger gene in autoimmune thyroid disease

关联疾病

疾病名称 别名
Autoimmune Thyroid Disease 3

Autoimmune Thyroid Disease, Susceptibility To, 3

AITD3

Autoimmune Thyroid Disease, Susceptibility To 3

Thyroid Disease, Autoimmune, Susceptibility To, Type 3
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16033 ZFAT Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZFAT VGNC VGNC:37154
Mus musculus ZFAT MGD MGI:2681865
Felis catus ZFAT VGNC VGNC:67227
Macaca mulatta ZFAT VGNC VGNC:79209
Rattus norvegicus ZFAT RGD RGD:1310886
Canis familiaris ZFAT VGNC VGNC:48604
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