2. Gene
  3. PTBP2 - polypyrimidine tract binding protein 2 Gene

PTBP2 - polypyrimidine tract binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚嘧啶束结合蛋白 2

种属: Homo sapiens

同用名: nPTB; PTBLP; brPTB

基因 ID: 58155 | 基因类型: protein coding

关于 PTBP2

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:96,721,784-96,823,739 (from NCBI)

This gene has 19 transcripts (splice variants), 277 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.6), brain (RPKM 9.8) and 24 other tissues.

功能概要

由该基因编码的蛋白质与 pre-mRNA 分子中的内含子聚嘧啶簇结合，并参与控制其他剪接调节蛋白的组装。这种蛋白质与聚嘧啶束结合蛋白 (PTB) 非常相似，但它的大多数亚型主要在大脑中表达。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of Other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

PTBP2 基因产物(8)

mRNA Protein Name
NM_001300985.2 NP_001287914.1 polypyrimidine tract-binding protein 2 isoform 1
NM_001300986.2 NP_001287915.1 polypyrimidine tract-binding protein 2 isoform 2
NM_001300987.2 NP_001287916.1 polypyrimidine tract-binding protein 2 isoform 3
NM_001300988.2 NP_001287917.1 polypyrimidine tract-binding protein 2 isoform 4
NM_001300989.2 NP_001287918.1 polypyrimidine tract-binding protein 2 isoform 5
NM_001300990.2 NP_001287919.1 polypyrimidine tract-binding protein 2 isoform 7
NM_001410833.1 NP_001397762.1 polypyrimidine tract-binding protein 2 isoform 8
NM_021190.4 NP_067013.1 polypyrimidine tract-binding protein 2 isoform 6
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26871637 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of RNA splicing IDA
IDA: 通过直接分析推断
18335065 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTBP2 蛋白结构

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (78 - 131)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (197 - 255)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (355 - 410)

(457 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
蛋白主名 其他名称

polypyrimidine tract-binding protein 2

PTB-like protein

PTBP2 抗体

目录号 产品名 应用 反应物种
HY-P83157 PTBP2 Antibody (YA2902) WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Patellar Tendinitis

Patellar Tendonitis
Adenoiditis

Chronic Adenoiditis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11352 PTBP2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PTBP2 MGD MGI:1860489
Felis catus PTBP2 VGNC VGNC:64421
Macaca mulatta PTBP2 VGNC VGNC:76280
Bos taurus PTBP2 VGNC VGNC:55667
Rattus norvegicus PTBP2 RGD RGD:1359267
Canis familiaris PTBP2 VGNC VGNC:54061
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