OPRPN - opiorphin prepropeptide Gene

中文名称：opiorphin 前肽原

种属: Homo sapiens

同用名: BPLP; PRL1; PROL1; opiorphin

关于 OPRPN

功能概要

该基因编码富含脯氨酸的蛋白质家族成员。编码的蛋白质具有多种拟定功能，包括抑制疼痛、阴茎勃起和保护眼睛表面的作用。 QRFSR 五肽，称为 opiorphin，源自该蛋白质的 N 末端。 Opiorphin 抑制脑啡肽失活肽酶脑啡肽酶和氨肽酶 N，并且这种活性被认为通过影响脑啡肽相关的阿片类药物依赖性途径的激活来降低对疼痛刺激的敏感性。 Opiorphin 也可以作为抗抑郁药。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 11 月]

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases Neprilysin and Aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]