2. Gene
  3. CACTIN - cactin, spliceosome C complex subunit Gene

CACTIN - cactin, spliceosome C complex subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：cactin，剪接体 C 复合亚基

种属: Homo sapiens

同用名: fSAPc; C19orf29; NY-REN-24

基因 ID: 58509 | 基因类型: protein coding

关于 CACTIN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,610,645-3,626,790 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 5.5), testis (RPKM 4.7) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与多个过程，包括细胞对细胞因子刺激的反应；细胞因子产生的负调节；和信号转导的负调节。位于胞质溶胶和核斑点。催化步骤 2 剪接体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CACTIN 基因产物(2)

mRNA Protein Name
NM_001080543.2 NP_001074012.1 cactin
NM_021231.2 NP_067054.1 cactin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20829348 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-1 IDA
IDA: 通过直接分析推断
20829348 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
20829348 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
20829348 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
28062851 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
20829348 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
26363554 GOA
involved in negative regulation of interferon-beta production IMP
IMP: 通过突变表型推断
20829348 GOA
involved in negative regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
20829348 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
20829348 GOA
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
20829348 GOA
involved in negative regulation of toll-like receptor signaling pathway IDA
IDA: 通过直接分析推断
20829348 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
20829348 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
20829348 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15302935 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CACTIN 蛋白结构

Cactin_mid

Cactin_mid: Conserved mid region of cactin (201 - 390)

CactinC_cactus

CactinC_cactus: Cactus-binding C-terminus of cactin protein (566 - 690)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 867 a.a.
蛋白主名 其他名称

cactin

NY REN 24 antigen

关联疾病

疾病名称 别名
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

Hypophosphatemic Nephrolithiasis/Osteoporosis 2

NPHLOP2

Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2

Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2
Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01816 CACTIN Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CACTIN RGD RGD:1563634
Bos taurus CACTIN VGNC VGNC:58364
Felis catus CACTIN VGNC VGNC:60313
Mus musculus CACTIN MGD MGI:1917562
Canis familiaris CACTIN VGNC VGNC:38653
Macaca mulatta CACTIN VGNC VGNC:108486
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z