2. Gene
  3. PZP - PZP alpha-2-macroglobulin like Gene

PZP - PZP alpha-2-macroglobulin like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PZP α-2-巨球蛋白样

种属: Homo sapiens

同用名: CPAMD6

基因 ID: 5858 | 基因类型: protein coding

关于 PZP

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,136,472-9,208,395 (from NCBI)

This gene has 7 transcripts (splice variants), 584 orthologues and 8 paralogues. Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues.

功能概要

该基因编码的蛋白质在妊娠晚期血清中高表达，其结构与α-2-巨球蛋白相似。编码的蛋白质作为同源四聚体，抑制所有四类蛋白酶的活性。该蛋白质含有几种蛋白酶的切割位点。结合蛋白酶后，该蛋白质的构象发生变化以捕获蛋白酶，从而限制其活性。这种蛋白质在症状前的阿尔茨海默氏病患者的血清中似乎有所升高。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

PZP 基因产物(1)

mRNA Protein Name
NM_002864.3 NP_002855.2 pregnancy zone protein precursor

PZP 蛋白结构

A2M_N

A2M_N: MG2 domain (128 - 220)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (455 - 603)

A2M

A2M: Alpha-2-macroglobulin family (744 - 834)

Thiol-ester_cl

Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (967 - 997)

A2M_comp

A2M_comp: A-macroglobulin complement component (1016 - 1271)

A2M_recep

A2M_recep: A-macroglobulin receptor (1382 - 1469)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1482 a.a.
蛋白主名 其他名称

pregnancy zone protein

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

关联疾病

疾病名称 别名
Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos
Inflammatory Bowel Disease 17

Inflammatory Bowel Disease 17, Protection Against

IBD17

Bowel Disease, Inflammatory, Type 17
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11498 PZP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19112 Pzp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25602 Pzp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PZP RGD RGD:621366
Others PZP NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z