2. Gene
  3. Nr1h3 - nuclear receptor subfamily 1, group H, member 3 Gene

Nr1h3 - nuclear receptor subfamily 1, group H, member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: LXRalpha

基因 ID: 58852 | 基因类型: protein coding

关于 Nr1h3

功能概要

Enables retinoid X receptor binding activity and sequence-specific DNA binding activity. Involved in several processes, including bile acid signaling pathway; Insulin Receptor signaling pathway; and response to Cholesterol. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and premature menopause. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h3 基因产物(1)

mRNA Protein Name
NM_031627.2 NP_113815.2 oxysterols receptor LXR-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear retinoid X receptor binding IPI
IPI: 通过物理相互作用推断
7935418 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
7935418 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7935418 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IEP
IEP: 通过表达模式推断
33770194 RGD
involved in digestive tract development IEP
IEP: 通过表达模式推断
17341476 RGD
involved in insulin receptor signaling pathway IEP
IEP: 通过表达模式推断
11781314 RGD
involved in liver development IEP
IEP: 通过表达模式推断
17341476 RGD
involved in regulation of fatty acid metabolic process IMP
IMP: 通过突变表型推断
26256083 RGD
involved in response to cholesterol IEP
IEP: 通过表达模式推断
25263431 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25263431 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
21136146 RGD
involved in spleen development IEP
IEP: 通过表达模式推断
17341476 RGD
involved in thymus development IEP
IEP: 通过表达模式推断
17341476 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
17341476 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

oxysterols receptor LXR-alpha

RLD-1

liver X receptor alpha

nuclear orphan receptor LXR-alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09530 NR1H3 Human Pre-designed siRNA Set A / 否
HY-RS22684 Nr1h3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29198 Nr1h3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr1h3 NCBI NCBI:10062
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