2. Gene
  3. Efemp2 - epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Gene

Efemp2 - epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MBP1; Fbln4; 0610011K11Rik

基因 ID: 58859 | 基因类型: protein coding

关于 Efemp2

功能概要

Predicted to enable heparin binding activity and protein homodimerization activity. Involved in several processes, including elastic fiber assembly; negative regulation of vascular associated smooth muscle cell proliferation; and vasculature development. Acts upstream of or within artery development. Located in basement membrane; elastic fiber; and microfibril. Is expressed in several structures, including central nervous system; genitourinary system; gut; immune system; and respiratory system. Used to study aortic aneurysm and cutis laxa. Human ortholog(s) of this gene implicated in aortic aneurysm; arterial tortuosity syndrome; autosomal recessive cutis laxa type IB; endometrial cancer; and osteosarcoma. Orthologous to human EFEMP2 (EGF containing fibulin extracellular matrix protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Efemp2 基因产物(3)

mRNA Protein Name
NM_001164352.1 NP_001157824.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform 2 precursor
NM_001374680.1 NP_001361609.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform 3 precursor
NM_021474.3 NP_067449.3 EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16478991 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aorta development IMP
IMP: 通过突变表型推断
20019329 MGI
involved in aorta smooth muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
26178373 MGI
acts upstream of or within artery development IMP
IMP: 通过突变表型推断
19855011 MGI
acts upstream of or within elastic fiber assembly IMP
IMP: 通过突变表型推断
19855011 MGI
involved in elastic fiber assembly IMP
IMP: 通过突变表型推断
16478991 MGI
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
23636094 MGI
involved in positive regulation of aortic smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
20019329 MGI
involved in positive regulation of collagen fibril organization IMP
IMP: 通过突变表型推断
26178373 MGI
involved in regulation of collagen fibril organization IMP
IMP: 通过突变表型推断
26690653 MGI
involved in vascular associated smooth muscle cell development IMP
IMP: 通过突变表型推断
23636094 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
17324935 MGI
located in elastic fiber IMP
IMP: 通过突变表型推断
16478991 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
17324935 MGI
located in microfibril IDA
IDA: 通过直接分析推断
17324935 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

EGF-containing fibulin-like extracellular matrix protein 2

EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)

FIBL-4

fibulin-4

mutant p53-binding protein 1

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04186 EFEMP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21849 Efemp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Efemp2 NCBI NCBI:30008
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