1. Gene
  2. ROBO1 - Robo1 roundabout guidance receptor 1 Gene

ROBO1 - Robo1 roundabout guidance receptor 1 Gene

种属: Rattus norvegicus

基因 ID: 58946 | 基因类型: protein coding

关于 ROBO1

功能概要

Enables axon guidance receptor activity. Involved in axon midline choice point recognition; regulation of dendrite morphogenesis; and spinal cord development. Located in axon and neuronal cell body. Biomarker of lung non-small cell carcinoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

ROBO1 基因产物(1)

mRNA Protein Name
NM_022188.2 NP_071524.2 roundabout homolog 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables axon guidance receptor activity IDA
IDA: 通过直接分析推断
9458045 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10102268 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon guidance IDA
IDA: 通过直接分析推断
9458045 RGD
involved in axon midline choice point recognition IEP
IEP: 通过表达模式推断
18986510 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
23994690 RGD
involved in negative regulation of synapse assembly IMP
IMP: 通过突变表型推断
27893610 RGD
involved in neuron projection extension IMP
IMP: 通过突变表型推断
26738857 RGD
involved in oligodendrocyte development IEP
IEP: 通过表达模式推断
22433866 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
11779479 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
10102268 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
18986510 RGD
located in dendrite IDA
IDA: 通过直接分析推断
26738857 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
18986510 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

roundabout homolog 1

roundabout, axon guidance receptor, homolog 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ROBO1 NCBI NCBI:6091