2. Gene
  3. Acan - aggrecan Gene

Acan - aggrecan Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Agc; Agc1

基因 ID: 58968 | 基因类型: protein coding

关于 Acan

功能概要

Enables calcium ion binding activity. Involved in several processes, including chondroblast differentiation; response to acidic pH; and response to glucose. Located in several cellular components, including extracellular space; neuronal cell body; and perineuronal net. Used to study degenerative disc disease. Biomarker of congestive heart failure; degenerative disc disease; osteoarthritis; and status epilepticus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan). [provided by Alliance of Genome Resources, Apr 2022]

Acan 基因产物(1)

mRNA Protein Name
NM_022190.2 NP_071526.2 aggrecan core protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
15296743 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
19968598 RGD
involved in chondroblast differentiation IEP
IEP: 通过表达模式推断
20001227 RGD
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
8641562 RGD
involved in ossification IEP
IEP: 通过表达模式推断
20047194 RGD
involved in response to acidic pH IEP
IEP: 通过表达模式推断
19133233 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
18670337 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
18245988 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
19968598 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18279833 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18628692 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
18364019 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
20603097 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
22306080 RGD
located in perineuronal net IDA
IDA: 通过直接分析推断
18364019 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aggrecan core protein

CSPCP

aggrecan 1

aggrecan, structural proteoglycan of cartilage

cartilage-specific proteoglycan core protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00132 ACAN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17876 Acan Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24345 Acan Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acan NCBI NCBI:176
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