2. Gene
  3. Nucb2 - nucleobindin 2 Gene

Nucb2 - nucleobindin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p54; Nefa

基因 ID: 59295 | 基因类型: protein coding

关于 Nucb2

功能概要

Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nucb2 基因产物(1)

mRNA Protein Name
NM_021663.2 NP_067695.1 nucleobindin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IDA
IDA: 通过直接分析推断
21653697 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
21653697 RGD
enables tumor necrosis factor receptor binding IPI
IPI: 通过物理相互作用推断
20649583 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in insulin metabolic process IDA
IDA: 通过直接分析推断
21828181 RGD
involved in negative regulation of appetite IMP
IMP: 通过突变表型推断
17036007 RGD
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: 通过直接分析推断
22486620 RGD
involved in negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
22486620 RGD
involved in negative regulation of glucagon secretion IDA
IDA: 通过直接分析推断
21828181 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
22486620 RGD
involved in positive regulation of fatty acid oxidation IDA
IDA: 通过直接分析推断
21828181 RGD
involved in positive regulation of testosterone secretion IDA
IDA: 通过直接分析推断
22334726 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
20032201 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
22334726 RGD
involved in response to melanocyte-stimulating hormone IEP
IEP: 通过表达模式推断
17036007 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
22334726 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: 通过直接分析推断
21653697 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi medial cisterna IDA
IDA: 通过直接分析推断
11893086 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
17036007 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nucleobindin-2

DNA-binding protein NEFA

nesfatin-1

prepronefastin

prepronesfatin

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09655 NUCB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS18672 Nucb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25158 Nucb2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nucb2 NCBI NCBI:4925
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