2. Gene
  3. RGS7 - regulator of G protein signaling 7 Gene

RGS7 - regulator of G protein signaling 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白信号调节因子 7

种属: Homo sapiens

基因 ID: 6000 | 基因类型: protein coding

关于 RGS7

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,774,742-241,357,230 (from NCBI)

This gene has 55 transcripts (splice variants), 233 orthologues, 23 paralogues and is associated with 85 phenotypes. Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues.

功能概要

启用 G 蛋白 β 亚基结合活性和 GTP 酶激活剂活性。参与 GTPase 活性的正向调节。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGS7 基因产物(20)

mRNA Protein Name
NM_001282773.2 NP_001269702.1 regulator of G-protein signaling 7 isoform 2
NM_001282775.2 NP_001269704.1 regulator of G-protein signaling 7 isoform 3
NM_001282778.2 NP_001269707.1 regulator of G-protein signaling 7 isoform 4
NM_001350113.2 NP_001337042.1 regulator of G-protein signaling 7 isoform 5
NM_001350114.2 NP_001337043.1 regulator of G-protein signaling 7 isoform 5
NM_001350115.2 NP_001337044.1 regulator of G-protein signaling 7 isoform 6
NM_001350116.1 NP_001337045.1 regulator of G-protein signaling 7 isoform 6
NM_001364886.1 NP_001351815.1 regulator of G-protein signaling 7 isoform 7
NM_001374806.1 NP_001361735.1 regulator of G-protein signaling 7 isoform 8
NM_001374807.1 NP_001361736.1 regulator of G-protein signaling 7 isoform 9
NM_001374808.1 NP_001361737.1 regulator of G-protein signaling 7 isoform 5
NM_001374809.1 NP_001361738.1 regulator of G-protein signaling 7 isoform 10
NM_001374810.1 NP_001361739.1 regulator of G-protein signaling 7 isoform 11
NM_001374811.1 NP_001361740.1 regulator of G-protein signaling 7 isoform 13
NM_001374812.1 NP_001361741.1 regulator of G-protein signaling 7 isoform 12
NM_001374813.1 NP_001361742.1 regulator of G-protein signaling 7 isoform 14
NM_001374814.1 NP_001361743.1 regulator of G-protein signaling 7 isoform 15
NM_001374815.1 NP_001361744.1 regulator of G-protein signaling 7 isoform 16
NM_001374816.1 NP_001361745.1 regulator of G-protein signaling 7 isoform 17
NM_002924.6 NP_002915.3 regulator of G-protein signaling 7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IDA
IDA: 通过直接分析推断
36996198 GOA
enables G-protein beta-subunit binding IPI
IPI: 通过物理相互作用推断
19376773 GOA
enables GTPase activator activity IDA
IDA: 通过直接分析推断
10521509 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
31189666 GOA
involved in negative regulation of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
36996198 GOA
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
10521509 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
10521509 GOA
is active in plasma membrane IDA
IDA: 通过直接分析推断
10521509 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGS7 蛋白结构

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (40 - 110)

G-gamma

G-gamma: GGL domain (255 - 315)

RGS

RGS: Regulator of G protein signaling domain (335 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
蛋白主名 其他名称

regulator of G-protein signaling 7

regulator of G-protein signaling RGS7

关联疾病

疾病名称 别名
Night Blindness, Congenital Stationary, Type 1b

Congenital Stationary Night Blindness 1b

CSNB1B

Night Blindness, Congenital Stationary, Complete, Autosomal Recessive

Csnb, Complete, Autosomal Recessive

Night Blindness, Congenital Stationary , 1b, Autosomal Recessive

Autosomal Recessive Complete Congenital Stationary Night Blindness

Congenital Stationary Night Blindness 1b Autosomal Recessive

Night Blindness, Congenital Stationary, 1b

Complete Autosomal Recessive Csnb

Complete Congenital Stationary Night Blindness Autosomal Recessive

Blindness, Night, Stationary, Congenital, Type 1b
Prolonged Electroretinal Response Suppression

Bradyopsia

PERRS
Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11925 RGS7 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RGS7 MGD MGI:1346089
Bos taurus RGS7 VGNC VGNC:33923
Canis familiaris RGS7 VGNC VGNC:45536
Macaca mulatta RGS7 VGNC VGNC:76692
Rattus norvegicus RGS7 RGD RGD:3570
Felis catus RGS7 VGNC VGNC:64598
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