2. Gene
  3. Birc2 - baculoviral IAP repeat-containing 2 Gene

Birc2 - baculoviral IAP repeat-containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含杆状病毒 IAP 重复 2

种属: Rattus norvegicus

同用名: Api2; rIAP1

基因 ID: 60371 | 基因类型: protein coding

关于 Birc2

Primary_assembly 8: 4,968,842-4,988,732 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Adrenal (RPKM 363.4), Thymus (RPKM 214.6) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 FBXO 家族蛋白结合活性；伴侣结合活动；和参与细胞凋亡过程的半胱氨酸型内肽酶抑制剂活性。参与响应 cAMP；对乙醇的反应；和对缺氧的反应。位于XY体内；膜筏；和核。部分含蛋白质复合物。该基因的人类直系同源物与乳腺癌有关。与人类 BIRC2 同源（杆状病毒 IAP 重复包含 2）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in response to cAMP; response to ethanol; and response to hypoxia. Located in XY body; membrane raft; and nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Birc2 基因产物(1)

mRNA Protein Name
NM_021752.3 NP_068520.2 baculoviral IAP repeat-containing protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15590916 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to cAMP IEP
IEP: 通过表达模式推断
11849428 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16687129 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
12023884 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
15371238 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in XY body IDA
IDA: 通过直接分析推断
16343737 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15590916 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Birc2 蛋白结构

BIR

BIR: smart00238 (23 - 92)

BIR

BIR: smart00238 (154 - 223)

BIR

BIR: smart00238 (239 - 307)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (361 - 407)

CARD_BIRC2_BIRC3

CARD_BIRC2_BIRC3: cd08329 (424 - 513)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (532 - 588)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 589 a.a.
蛋白主名 其他名称

baculoviral IAP repeat-containing protein 2

apoptosis inhibitor 2

inhibitor of apoptosis protein

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50685 A 410099.1 Inhibitor 99.30% 否
HY-RS01507 BIRC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01509 Birc2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Birc2 NCBI NCBI:329
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