2. Gene
  3. PPCDC - phosphopantothenoylcysteine decarboxylase Gene

PPCDC - phosphopantothenoylcysteine decarboxylase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸泛酰半胱氨酸脱羧酶

种属: Homo sapiens

同用名: coaC; MDS018; PPC-DC

基因 ID: 60490 | 基因类型: protein coding

关于 PPCDC

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,023,590-75,050,726 (from NCBI)

This gene has 11 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 1.6), appendix (RPKM 1.5) and 25 other tissues.

功能概要

从泛酸 (维生素 B5) 生物合成辅酶 A (CoA) 是原核生物和真核生物中必不可少的通用途径。 PPCDC (EC 4.1.1.36) ，该途径中的最后一种酶，将磷酸泛酰半胱氨酸转化为 4-主要磷酸泛硫因 (Daugherty 等人，2002 [PubMed 11923312]) 。[OMIM 提供，2008 年 3 月]

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

PPCDC 基因产物(6)

mRNA Protein Name
NM_001301101.2 NP_001288030.1 phosphopantothenoylcysteine decarboxylase isoform b
NM_001301102.2 NP_001288031.1 phosphopantothenoylcysteine decarboxylase isoform c
NM_001301103.2 NP_001288032.1 phosphopantothenoylcysteine decarboxylase isoform d
NM_001301104.2 NP_001288033.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_001301105.2 NP_001288034.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_021823.5 NP_068595.3 phosphopantothenoylcysteine decarboxylase isoform a

PPCDC 蛋白结构

Flavoprotein

Flavoprotein: Flavoprotein (19 - 149)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

phosphopantothenoylcysteine decarboxylase

重组 PPCDC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71222 PPC-DC Protein, Human (His) Q96CD2-1 (M1-S204) ≥95%
HY-P71222A PPC-DC Protein, Human (His, solution) Q96CD2-1 (M1-S204) ≥95%

关联疾病

疾病名称 别名
Cecum Carcinoma

Cecum Cancer

Caecum Carcinoma

Carcinoma Of Cecum

Cecal Cancer

Malignant Neoplasm Of Caecum

Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum
Thyroid Dyshormonogenesis 6

TDH6

Genetic Defect In Thyroid Hormonogenesis 6

Thyroid Hormonogenesis, Genetic Defect In, 6

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6

Chdh6

Congenital Hypothyroidism Due To Dyshormonogenesis Type 6
Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon
Neurodegeneration With Brain Iron Accumulation 1

Pantothenate Kinase-Associated Neurodegeneration

Pkan

NBIA1

Hallervorden-Spatz Disease

Hallervorden-Spatz Syndrome

Pigmentary Pallidal Degeneration

Neuroaxonal Dystrophy, Late Infantile

Neurodegeneration With Brain Iron Accumulation Type 1

Classic Pantothenate Kinase-Associated Neurodegeneration

Pkan Neuroaxonal Dystrophy, Juvenile-Onset

Brain Iron Accumulation Type I Syndrome

Nbia

Neurodegeneration With Brain Iron Accumulation

Nbia1, Classic Form

Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form

Pkan, Classic Form

Atypical Pantothenate Kinase-Associated Neurodegeneration

Nbia1, Atypical Form

Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form

Pkan, Atypical Form

Hss

Pkan Neuroaxonal Dystrophy Juvenile-Onset

Neurodegeneration, With Brain Iron Accumulation, Type 1
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10934 PPCDC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPCDC VGNC VGNC:64306
Rattus norvegicus PPCDC RGD RGD:1306267
Mus musculus PPCDC MGD MGI:1914062
Bos taurus PPCDC VGNC VGNC:33188
Macaca mulatta PPCDC VGNC VGNC:76124
Canis familiaris PPCDC VGNC VGNC:44840
Others PPCDC NCBI
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