1. Gene
  2. DHX35 - DEAH-box helicase 35 Gene

DHX35 - DEAH-box helicase 35 Gene

中文名称:DEAH 盒解旋酶 35

种属: Homo sapiens

同用名: DDX35; C20orf15; KAIA0875

基因 ID: 60625 | 基因类型: protein coding

关于 DHX35

This gene has 8 transcripts (splice variants), 200 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 6.1), endometrium (RPKM 6.0) and 25 other tissues.

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程,例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式,DEAD box 蛋白家族的一些成员被认为参与胚胎发生、精子发生以及细胞生长和分裂。作为该家族成员的该基因产物的功能尚未确定。已发现该基因的可变剪接转录物变体。[RefSeq 提供,2010 年 6 月]

DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]

DHX35 基因产物(2)

mRNA Protein Name
NM_001190809.2 NP_001177738.1 probable ATP-dependent RNA helicase DHX35 isoform 2
NM_021931.4 NP_068750.2 probable ATP-dependent RNA helicase DHX35 isoform 1
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DHX35 蛋白结构

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (307 - 397)

HA2

HA2: Helicase associated domain (HA2) (458 - 549)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (584 - 684)

  • 0
  • 200
  • 400
  • 600
  • 703 a.a.
蛋白主名 其他名称

probable ATP-dependent RNA helicase DHX35

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35

关联疾病

疾病名称 别名
Cranioectodermal Dysplasia 2

CED2

Sensenbrenner Syndrome 2

Dysplasia, Cranioectodermal, Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DHX35 VGNC VGNC:39945
Rattus norvegicus DHX35 RGD RGD:1311165
Mus musculus DHX35 MGD MGI:1918965
Felis catus DHX35 VGNC VGNC:61480
Bos taurus DHX35 VGNC VGNC:28053