2. Gene
  3. RPLP1 - ribosomal protein lateral stalk subunit P1 Gene

RPLP1 - ribosomal protein lateral stalk subunit P1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白侧柄亚基 P1

种属: Homo sapiens

同用名: P1; LP1; RPP1

基因 ID: 6176 | 基因类型: protein coding

关于 RPLP1

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,452,818-69,456,205 (from NCBI)

This gene has 5 transcripts (splice variants), 152 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 1137.8), ovary (RPKM 979.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码一种核糖体磷蛋白，它是 60S 亚基的一个组成部分。该蛋白质是大肠杆菌 L7/L12 核糖体蛋白的功能等价物，属于核糖体蛋白 L12P 家族。它在蛋白质合成的延伸步骤中起重要作用。与大多数碱性核糖体蛋白不同，编码的蛋白质是酸性的。它的 C 末端与核糖体磷蛋白 P0 和 P2 的 C 末端几乎相同。 P1 蛋白可以与 P0 和 P2 相互作用，形成由 P1 和 P2 二聚体以及一个 P0 单体组成的五聚体复合物。该蛋白质位于细胞质中。已经观察到编码不同蛋白质的两种选择性剪接的转录物变体。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPLP1 基因产物(2)

mRNA Protein Name
NM_001003.3 NP_000994.1 60S acidic ribosomal protein P1 isoform 1
NM_213725.2 NP_998890.1 60S acidic ribosomal protein P1 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12054647 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
3323886 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
3323886 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPLP1 蛋白结构

Ribosomal_60s

Ribosomal_60s: 60s Acidic ribosomal protein (23 - 113)

  • 0
  • 100
  • 114 a.a.
蛋白主名 其他名称

60S acidic ribosomal protein P1

acidic ribosomal phosphoprotein P1

RPLP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPLP1 P05386 RPLP2 Homo sapiens P05387
NMR
22135285
种属内
RPLP1 P05386 RPLP2 Homo sapiens P05387
Pull Down
22135285
种属内
RPLP1 P05386 SUOX Homo sapiens P51687
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RPLP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76581 RPLP1 Protein, Human (sf9, His) P05386-1/NP_000994.1 (M1-D114) ≥95%

关联疾病

疾病名称 别名
Branchiootorenal Syndrome 2

BOR2

Bor Syndrome 2

Branchiootorenal Dysplasia 2

Branchio-Oto-Renal Dysplasia 2

Branchio-Oto-Renal Syndrome Type 2

Branchiootorenal Syndrome, Type 2
Melanotic Neuroectodermal Tumor

Melanotic Neuroectodermal Tumor Of Infancy

Neuroectodermal Tumor, Melanotic

Infantile Melanotic Neuroectodermal Neoplasm

Melanotic Neuroectodermal Tumour

Melanotic Neuroectodermal Tumour Of Infancy

Pigmented Neuroectodermal Tumour Of Infancy
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12208 RPLP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20484 Rplp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26992 Rplp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPLP1 MGD MGI:1927099
Rattus norvegicus RPLP1 RGD RGD:621774
Bos taurus RPLP1 VGNC VGNC:55142
Others RPLP1 NCBI
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