1. Gene
  2. DMRTA2 - DMRT like family A2 Gene

DMRTA2 - DMRT like family A2 Gene

中文名称:DMRT 样家族 A2

种属: Homo sapiens

基因 ID: 63950 | 基因类型: protein coding

关于 DMRTA2

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:50,417,550-50,423,443 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 8 paralogues. Low expression observed in reference dataset.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调节和性别分化。预计在神经系统发育和骨骼肌细胞分化的上游或内部起作用。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within nervous system development and skeletal muscle cell differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DMRTA2 基因产物(1)

mRNA Protein Name
NM_032110.3 NP_115486.1 doublesex- and mab-3-related transcription factor A2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DMRTA2 蛋白结构

DM

DM: DM DNA binding domain (66 - 112)

DMA

DMA: DMRTA motif (313 - 351)

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  • 542 a.a.
蛋白主名 其他名称

doublesex- and mab-3-related transcription factor A2

doublesex- and mab-3-related transcription factor 5

直系同源

种属 基因名 来源 基因 ID
Mus musculus DMRTA2 MGD MGI:2653629
Macaca mulatta DMRTA2 VGNC VGNC:106349
Felis catus DMRTA2 VGNC VGNC:107523
Bos taurus DMRTA2 VGNC VGNC:28114
Rattus norvegicus DMRTA2 RGD RGD:1308173