2. Gene
  3. NEUROG2 - neurogenin 2 Gene

NEUROG2 - neurogenin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经发生素 2

种属: Homo sapiens

同用名: NGN2; Atoh4; ngn-2; Math4A; bHLHa8

基因 ID: 63973 | 基因类型: protein coding

关于 NEUROG2

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:112,513,516-112,516,180 (from NCBI)

This gene has 1 transcript (splice variant), 113 orthologues and 15 paralogues. Restricted expression toward testis (RPKM 1.1).

功能概要

该基因编码神经特异性基本螺旋-环-螺旋 (bHLH) 转录因子，可指定外胚层细胞的神经元命运，并在发育中的中枢和周围神经系统内的神经祖细胞中表达。该基因的蛋白质产物还在中脑多巴胺能神经元的分化和存活中发挥作用。[RefSeq 提供，2012 年 4 月]

This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

NEUROG2 基因产物(1)

mRNA Protein Name
NM_024019.4 NP_076924.1 neurogenin-2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEUROG2 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (113 - 164)

  • 0
  • 100
  • 200
  • 272 a.a.
蛋白主名 其他名称

neurogenin-2

class A basic helix-loop-helix protein 8

NEUROG2 抗体

目录号 产品名 应用 反应物种
HY-P82782 Neurogenin 2 Antibody (YA2527) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09229 NEUROG2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NEUROG2 RGD RGD:1309061
Canis familiaris NEUROG2 VGNC VGNC:43757
Bos taurus NEUROG2 VGNC VGNC:32022
Macaca mulatta NEUROG2 VGNC VGNC:75170
Felis catus NEUROG2 VGNC VGNC:63785
Mus musculus NEUROG2 MGD MGI:109619
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z