2. Gene
  3. SEMA3F - semaphorin 3F Gene

SEMA3F - semaphorin 3F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号蛋白 3F

种属: Homo sapiens

同用名: SEMA4; SEMAK; SEMA-IV

基因 ID: 6405 | 基因类型: protein coding

关于 SEMA3F

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,155,058-50,189,075 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues.

功能概要

该基因编码分泌信号蛋白信号蛋白 III 家族的成员，这些信号蛋白参与神经元发育过程中的轴突导向。编码的蛋白质包含一个 N 端 Sema 结构域、一个免疫球蛋白环和一个 C 端碱性结构域。该基因由内皮细胞表达，发现它以自分泌方式起作用以诱导细胞凋亡、抑制细胞增殖和存活，并作为抗肿瘤发生剂发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce Apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

SEMA3F 基因产物(3)

mRNA Protein Name
NM_001318798.2 NP_001305727.1 semaphorin-3F isoform 3
NM_001318800.2 NP_001305729.1 semaphorin-3F isoform 2 precursor
NM_004186.5 NP_004177.3 semaphorin-3F isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemorepellent activity IDA
IDA: 通过直接分析推断
15814794 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axon guidance IDA
IDA: 通过直接分析推断
15814794 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEMA3F 蛋白结构

Sema

Sema: Sema domain (57 - 529)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
蛋白主名 其他名称

semaphorin-3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

重组 SEMA3F 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71674 Semaphorin-3F/SEMA3F Protein, Human (HEK293, His-Myc) Q13275 (S19-T785) ≥95%

关联疾病

疾病名称 别名
Neuroma
Megacolon

Dilatation Of Colon
Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract
Cone-Rod Dystrophy 10

CORD10

Dystrophy, Cone-Rod, Type 10
Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12655 SEMA3F Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20594 Sema3f Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27102 Sema3f Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SEMA3F VGNC VGNC:77164
Rattus norvegicus SEMA3F RGD RGD:1308514
Canis familiaris SEMA3F VGNC VGNC:45992
Mus musculus SEMA3F MGD MGI:1096347
Bos taurus SEMA3F VGNC VGNC:34431
Felis catus SEMA3F VGNC VGNC:64990
Others SEMA3F NCBI
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