2. Gene
  3. Perp - PERP, TP53 apoptosis effector Gene

Perp - PERP, TP53 apoptosis effector Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: THW; KCP1; PIGPC1; KRTCAP1; 1110017A08Rik

基因 ID: 64058 | 基因类型: protein coding

关于 Perp

功能概要

Acts upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Located in Golgi apparatus and mitochondrion. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; limb primordium; sensory organ; and skin. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 Apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Apr 2022]

Perp 基因产物(1)

mRNA Protein Name
NM_022032.4 NP_071315.1 p53 apoptosis effector related to PMP-22
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
23117660 MGI
acts upstream of or within amelogenesis IMP
IMP: 通过突变表型推断
21285247 MGI
acts upstream of or within desmosome organization IMP
IMP: 通过突变表型推断
21285247 MGI
acts upstream of or within heterotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
21285247 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: 通过直接分析推断
10733530 MGI
involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
22515648 MGI
involved in positive regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
29740445 MGI
involved in tissue homeostasis IMP
IMP: 通过突变表型推断
22515648 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
10733530 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
25486861 MGI
located in desmosome IDA
IDA: 通过直接分析推断
22515648 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
10733530 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10733530 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

p53 apoptosis effector related to PMP-22

KCP-1

keratinocyte-associated protein 1

p53 apoptosis effector related to Pmp22

p53 apoptosis-associated target

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10335 PERP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18632 Perp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25118 Perp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Perp NCBI NCBI:64065
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