SELENOP - selenoprotein P Gene

中文名称：硒蛋白 P

种属: Homo sapiens

同用名: SeP; SELP; SEPP; SEPP1

基因 ID: 6414 | 基因类型: protein coding

关于 SELENOP

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:42,799,880-42,811,892 (from NCBI)

This gene has 15 transcripts (splice variants) and 177 orthologues. Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues.

功能概要

该基因编码一种主要在肝脏中表达并分泌到血浆中的硒蛋白。这种硒蛋白的独特之处在于其每个多肽含有多个硒代半胱氨酸 (Sec) 残基 (人类中有 10 个) ，并且占血浆中硒的大部分。它被认为是一种细胞外抗氧化剂，并通过载脂蛋白 E 受体 2 (apoER2) 将硒转运至肝外组织。缺乏该基因的小鼠表现出神经功能障碍，表明其在正常脑功能中的重要性。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。这种硒蛋白的 mRNA 包含两个 SECIS 元件。使用替代聚腺苷酸化位点，一个位于两个 SECIS 元素之间，导致两个 mRNA 群体包含两者 (主要) 或仅包含上游 SECIS 元素 (PMID：27881738) 。还发现了该基因的可变剪接转录物变体。[RefSeq 提供，2018 年 10 月]

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via Apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]

SELENOP 基因产物(3)

mRNA	Protein	Name
NM_001085486.3	NP_001078955.1	selenoprotein P isoform 1 precursor
NM_001093726.3	NP_001087195.1	selenoprotein P isoform 2
NM_005410.4	NP_005401.3	selenoprotein P isoform 1 precursor

SELENOP 蛋白结构

SelP_N

SelP_C

0
100
200
300
381 a.a.

蛋白主名

其他名称

selenoprotein P

selenoprotein P, plasma, 1

关联疾病

疾病名称

别名

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diabetes Mellitus

Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12641	SELENOP Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18579	Selenop Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25063	Selenop Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SELENOP	MGD	MGI:894288
Rattus norvegicus	SELENOP	RGD	RGD:3660
Bos taurus	SELENOP	VGNC	VGNC:109401
Others	SELENOP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SELENOP - selenoprotein P Gene

关于 SELENOP

功能概要

SELENOP 基因产物(3)

SELENOP 蛋白结构

关联疾病

直系同源

热门区域

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SELENOP - selenoprotein P Gene

关于 SELENOP

功能概要

SELENOP 基因产物(3)

SELENOP 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z