2. Gene
  3. Pfn1 - profilin 1 Gene

Pfn1 - profilin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 64303 | 基因类型: protein coding

关于 Pfn1

功能概要

Enables phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Located in cytoplasm; neuron projection; and synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfn1 基因产物(1)

mRNA Protein Name
NM_022511.2 NP_071956.2 profilin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
16741017 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12967995 RGD
enables signaling receptor binding IDA
IDA: 通过直接分析推断
10966486 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
10703666 RGD
involved in positive regulation of DNA metabolic process IDA
IDA: 通过直接分析推断
10966486 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
12740026 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10966486 RGD
involved in positive regulation of viral transcription IMP
IMP: 通过突变表型推断
12740026 RGD
involved in response to tetrachloromethane IEP
IEP: 通过表达模式推断
8297366 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
15654839 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
15654839 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
15654839 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
15654839 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

profilin-1

profilin I

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136808 Pfn1-IN-1 99.17% 否
HY-116903 Pfn1-IN-2 / 否
HY-RS10368 PFN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22276 Pfn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28799 Pfn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pfn1 NCBI NCBI:5216
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