1. Gene
  2. CDH22 - cadherin 22 Gene

CDH22 - cadherin 22 Gene

中文名称:钙粘蛋白 22

种属: Homo sapiens

同用名: C20orf25; dJ998H6.1

基因 ID: 64405 | 基因类型: protein coding

关于 CDH22

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,173,739-46,308,498 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 33 paralogues. Biased expression in brain (RPKM 3.4), skin (RPKM 1.8) and 4 other tissues.

功能概要

该基因是钙粘蛋白超家族的成员。该基因产物由五个钙粘蛋白重复结构域和一个类似于经典钙粘蛋白高度保守的细胞质区域的细胞质尾部组成。这种推定的钙依赖性细胞粘附蛋白主要在大脑中表达,在大脑和神经内分泌器官的发育和维持过程中,可能在神经和非神经细胞的形态发生和组织形成中发挥重要作用。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Cadherin superfamily. The gene product is composed of five Cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical Cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]

CDH22 基因产物(1)

mRNA Protein Name
NM_021248.3 NP_067071.1 cadherin-22 precursor

CDH22 蛋白结构

Cadherin

Cadherin: Cadherin domain (71 - 158)

Cadherin

Cadherin: Cadherin domain (174 - 268)

Cadherin

Cadherin: Cadherin domain (282 - 363)

Cadherin

Cadherin: Cadherin domain (402 - 490)

Cadherin

Cadherin: Cadherin domain (503 - 600)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (649 - 818)

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  • 200
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  • 600
  • 828 a.a.
蛋白主名 其他名称

cadherin-22

PB-cadherin

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CDH22 VGNC VGNC:39030
Macaca mulatta CDH22 VGNC VGNC:70940
Mus musculus CDH22 MGD MGI:1341843
Bos taurus CDH22 VGNC VGNC:27100
Felis catus CDH22 VGNC VGNC:60680
Rattus norvegicus CDH22 RGD RGD:2321