GZF1 - GDNF inducible zinc finger protein 1 Gene

中文名称：GDNF 诱导型锌指蛋白 1

种属: Homo sapiens

同用名: JLSM; ZBTB23; ZNF336

基因 ID: 64412 | 基因类型: protein coding

关于 GZF1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,361,127-23,373,062 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues, 51 paralogues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 10.9), bone marrow (RPKM 10.5) and 25 other tissues.

功能概要

启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调控区域序列特异性 DNA 结合活性。参与 RNA 聚合酶 II 对转录的负调控。位于核仁和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GZF1 基因产物(3)

mRNA	Protein	Name
NM_001317012.2	NP_001303941.1	GDNF-inducible zinc finger protein 1 isoform a
NM_001317019.1	NP_001303948.1	GDNF-inducible zinc finger protein 1 isoform b
NM_022482.5	NP_071927.1	GDNF-inducible zinc finger protein 1 isoform a

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16049025	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	16049025	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16049025	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	16049025	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16049025	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16049025	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16049025	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16049025	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GZF1 蛋白结构

BTB

zf-C2H2_6

zf-C2H2

zf-C2H2_4

zf-C2H2_6

zf-H2C2_2

0
200
400
600
711 a.a.

蛋白主名

其他名称

GDNF-inducible zinc finger protein 1

zinc finger and BTB domain-containing protein 23

关联疾病

疾病名称

别名

Joint Laxity, Short Stature, And Myopia

JLSM	Severe Myopia-Generalized Joint Laxity-Short Stature Syndrome

Pectus Carinatum

Carinatum Deformity Of The Chest

Larsen Syndrome

LRS	Larsen Syndrome, Dominant Type
Dominant Larsen Syndrome	Autosomal Dominant Larsen Syndrome
Larsens Syndrome

Acute Salpingitis

Glycogen Storage Disease Ix

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05938	GZF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	GZF1	VGNC	VGNC:62744
Rattus norvegicus	GZF1	RGD	RGD:1562321
Canis familiaris	GZF1	VGNC	VGNC:41576
Macaca mulatta	GZF1	VGNC	VGNC:73173
Bos taurus	GZF1	VGNC	VGNC:29732
Mus musculus	GZF1	MGD	MGI:1921783
Others	GZF1	NCBI

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