2. Gene
  3. NDST4 - N-deacetylase and N-sulfotransferase 4 Gene

NDST4 - N-deacetylase and N-sulfotransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-脱乙酰酶和 N-磺基转移酶 4

种属: Homo sapiens

同用名: N-HSST; NDST-4; NHSST4; N-HSST 4

基因 ID: 64579 | 基因类型: protein coding

关于 NDST4

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:114,827,763-115,113,620 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 10 paralogues. Low expression observed in reference dataset.

功能概要

预计可启用[硫酸乙酰肝素]-氨基葡萄糖 N-磺基转移酶活性和脱乙酰酶活性。预计参与硫酸乙酰肝素蛋白多糖生物合成过程、多糖链生物合成过程。预测位于高尔基体膜。预计是膜的组成部分。预测在高尔基体中活跃。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

NDST4 基因产物(1)

mRNA Protein Name
NM_022569.3 NP_072091.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

NDST4 蛋白结构

HSNSD

HSNSD: heparan sulfate-N-deacetylase (20 - 505)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (595 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 872 a.a.
蛋白主名 其他名称

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4

关联疾病

疾病名称 别名
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09121 NDST4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22675 Ndst4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29189 Ndst4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NDST4 VGNC VGNC:78530
Mus musculus NDST4 MGD MGI:1932545
Macaca mulatta NDST4 VGNC VGNC:100253
Rattus norvegicus NDST4 RGD RGD:1306531
Canis familiaris NDST4 VGNC VGNC:43684
Bos taurus NDST4 VGNC VGNC:31943
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