2. Gene
  3. EXO5 - exonuclease 5 Gene

EXO5 - exonuclease 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核酸外切酶 5

种属: Homo sapiens

同用名: DEM1; Exo V; hExo5; C1orf176

基因 ID: 64789 | 基因类型: protein coding

关于 EXO5

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,508,767-40,516,038 (from NCBI)

This gene has 11 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in lymph node (RPKM 2.5), appendix (RPKM 2.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种单链 DNA (ssDNA) 特异性核酸外切酶，可以在切割 DNA 之前沿着 DNA 滑动。然而，人类复制蛋白 A 结合 ssDNA 并限制编码蛋白的滑动，为酶提供 5' 方向性。这种蛋白质定位于 DNA 损伤后的核修复位点。[RefSeq 提供，2016 年 11 月]

The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]

EXO5 基因产物(12)

mRNA Protein Name
NM_001346946.2 NP_001333875.1 exonuclease V
NM_001346947.2 NP_001333876.1 exonuclease V
NM_001346948.2 NP_001333877.1 exonuclease V
NM_001346949.2 NP_001333878.1 exonuclease V
NM_001346950.2 NP_001333879.1 exonuclease V
NM_001346951.2 NP_001333880.1 exonuclease V
NM_001346952.2 NP_001333881.1 exonuclease V
NM_001346953.2 NP_001333882.1 exonuclease V
NM_001346954.2 NP_001333883.1 exonuclease V
NM_001346955.2 NP_001333884.1 exonuclease V
NM_001346956.2 NP_001333885.1 exonuclease V
NM_022774.3 NP_073611.1 exonuclease V
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 4 iron, 4 sulfur cluster binding IDA
IDA: 通过直接分析推断
23095756 GOA
enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
IDA: 通过直接分析推断
23095756 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interstrand cross-link repair IMP
IMP: 通过突变表型推断
23095756 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23095756 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23095756 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EXO5 蛋白结构

Exo5

Exo5: Exonuclease V - a 5' deoxyribonuclease (71 - 355)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

exonuclease V

defects in morphology 1 homolog

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04586 EXO5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris EXO5 VGNC VGNC:40512
Macaca mulatta EXO5 VGNC VGNC:72361
Mus musculus EXO5 MGD MGI:1920422
Rattus norvegicus EXO5 RGD RGD:1309802
Felis catus EXO5 VGNC VGNC:61997
Bos taurus EXO5 VGNC VGNC:59180
Others EXO5 NCBI
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