2. Gene
  3. METTL4 - methyltransferase 4, N6-adenosine Gene

METTL4 - methyltransferase 4, N6-adenosine Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：甲基转移酶 4，N6-腺苷

种属: Homo sapiens

同用名: HsT661

基因 ID: 64863 | 基因类型: protein coding

关于 METTL4

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,537,530-2,571,505 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), thyroid (RPKM 3.9) and 25 other tissues.

功能概要

启用 RNA 甲基转移酶活性和位点特异性 DNA 甲基转移酶 (腺嘌呤特异性) 活性。参与核酸代谢过程；调节 RNA 代谢过程；和线粒体 DNA 复制的调节。位于胞质溶胶中；线粒体基质；和核。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL4 基因产物(2)

mRNA Protein Name
NM_001308401.2 NP_001295330.1 N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_022840.5 NP_073751.3 N(6)-adenine-specific methyltransferase METTL4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA methyltransferase activity IDA
IDA: 通过直接分析推断
31913360 GOA
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
IDA: 通过直接分析推断
32183942 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of RNA splicing IMP
IMP: 通过突变表型推断
31913360 GOA
involved in regulation of mitochondrial DNA replication IMP
IMP: 通过突变表型推断
32183942 GOA
involved in regulation of mitochondrial transcription IMP
IMP: 通过突变表型推断
32183942 GOA
involved in snRNA (adenine-N6)-methylation IDA
IDA: 通过直接分析推断
31913360 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA N6-methyladenosine methyltransferase complex IMP
IMP: 通过突变表型推断
36354136 GOA
located in cytosol IDA
IDA: 通过直接分析推断
32183942 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
32183942 GOA
located in nucleus IDA
IDA: 通过直接分析推断
31913360 GOA
part of oxidoreductase complex IMP
IMP: 通过突变表型推断
36354136 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

METTL4 蛋白结构

MT-A70

MT-A70: MT-A70 (281 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
蛋白主名 其他名称

N(6)-adenine-specific methyltransferase METTL4

N(6)-adenine-specific DNA methyltransferase METTL4

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08365 METTL4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21883 Mettl4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28400 Mettl4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus METTL4 VGNC VGNC:63466
Bos taurus METTL4 VGNC VGNC:31413
Mus musculus METTL4 MGD MGI:1924031
Macaca mulatta METTL4 VGNC VGNC:81474
Rattus norvegicus METTL4 RGD RGD:1306451
Canis familiaris METTL4 VGNC VGNC:43178
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