1. Gene
  2. SKOR2 - SKI family transcriptional corepressor 2 Gene

SKOR2 - SKI family transcriptional corepressor 2 Gene

中文名称:SKI 家族转录辅阻遏物 2

种属: Homo sapiens

同用名: CORL2; CH18515; FUSSEL18

基因 ID: 652991 | 基因类型: protein coding

关于 SKOR2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:47,206,169-47,251,660 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 3 paralogues. Low expression observed in reference dataset.

功能概要

启用 SMAD 结合活性和序列特异性双链 DNA 结合活性。参与转化生长因子β受体信号通路的负调控。位于细胞质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SKOR2 基因产物(2)

mRNA Protein Name
NM_001037802.3 NP_001032891.1 SKI family transcriptional corepressor 2 isoform 2
NM_001278063.4 NP_001264992.1 SKI family transcriptional corepressor 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IPI
IPI: 通过物理相互作用推断
16200078 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
16200078 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16200078 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16200078 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SKOR2 蛋白结构

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (22 - 132)

c-SKI_SMAD_bind

c-SKI_SMAD_bind: c-SKI Smad4 binding domain (144 - 236)

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  • 1001 a.a.
蛋白主名 其他名称

SKI family transcriptional corepressor 2

LBX1 corepressor 1-like protein

直系同源

种属 基因名 来源 基因 ID
Felis catus SKOR2 VGNC VGNC:107724
Bos taurus SKOR2 VGNC VGNC:56373
Rattus norvegicus SKOR2 RGD RGD:1598071
Macaca mulatta SKOR2 VGNC VGNC:104247
Mus musculus SKOR2 MGD MGI:3645984